ID A0A085NLA1_9BILA Unreviewed; 808 AA.
AC A0A085NLA1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=XPG I-region {ECO:0000313|EMBL:KHJ40895.1};
GN ORFNames=D918_09005 {ECO:0000313|EMBL:KHJ40895.1}, M514_09205
GN {ECO:0000313|EMBL:KFD70247.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD70247.1};
RN [1] {ECO:0000313|EMBL:KFD70247.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD70247.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
RN [2] {ECO:0000313|EMBL:KHJ40895.1, ECO:0000313|Proteomes:UP000053709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mitreva M.;
RT "Draft genome of Trichuris suis.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
CC {ECO:0000256|ARBA:ARBA00005283}.
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DR EMBL; KL367489; KFD70247.1; -; Genomic_DNA.
DR EMBL; KN538426; KHJ40895.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085NLA1; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR Proteomes; UP000053709; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd09868; PIN_XPG_RAD2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR001044; XPG/Rad2_eukaryotes.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR16171:SF7; DNA EXCISION REPAIR PROTEIN ERCC-5; 1.
DR PANTHER; PTHR16171; DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR PRINTS; PR00066; XRODRMPGMNTG.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053709}.
FT DOMAIN 1..101
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 511..580
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 303..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 90218 MW; B6C597531F0AE052 CRC64;
MGVKGLWKLL QPSSRLIKLD CLEGTKLSVD LSIWLHQAIH ARVVAAISGS DEPRVHLQLL
FHRLLKLLFY GIRAIFVFDG PEVSSLKKRT QLLRRLRVNQ ATLKCRRTHA KLVKHIATVH
FSKAEEGRQL LSSSNSTSND SCMPKDVSAN SYSLLEVADG ADDDKSDSQL SPKRSPSPTL
WDNLAAFDLP SCSSIDPQCM AALPSELQFQ LYASKKSASC SLEDLPEDSA DFSTAQMKRL
VNRSELSEKM SRLRNEIILS DPVIALSLSV GQADSNLVRL RKMLSRDQKH HVLLEDEATA
QVKEENEQKL NVQSNSHTGR QQHELESSLH ATTDEPDASI TVGADLVEEE DLLVSVRKEH
DGDDVDRSTK VSNSSSASLE VLDAESSSRN TLSTICIPSE DIRSSERTPT EHDHNSSVVL
SSPSTDDSDD FIEVEEPTEP INRPLLLSSQ PLARSPSLES IGSSSSSSKD ASPDGDHEDN
IDLLRKERMH AEAAEKNVTS QILEECEELI RSFGMPVVKG PAEAEAQCAW LEENNITEGT
ITDDSDIWLF GGRRVYRHLF NVKKTVERFD MNTITNIYGL DRERLVLLAM LVGCDYTVGV
EGIGAVRATE IIAEFDPTKE DQTSDRLECL RLFRAWCERI INGNNHGDTD EPVTRERFAK
LAHCQFPGSF PDPLIFDAFL RPRVDQVDDR TLSWNLPDVD KIRNLTSSWF GWSKEQTDRH
LLPVVKRAAA LQSKRQKRLD DFCTTVAPTL SNSQVAPLSQ RVKRATSRLK ATVHNRKRRQ
SSQAPDTSSK LAGWCPSEAD KPKRSRLT
//
