ID A0A085NM83_9BILA Unreviewed; 2842 AA.
AC A0A085NM83;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Neurofibromin {ECO:0008006|Google:ProtNLM};
GN ORFNames=M514_02099 {ECO:0000313|EMBL:KFD70579.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD70579.1};
RN [1] {ECO:0000313|EMBL:KFD70579.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD70579.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
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DR EMBL; KL367487; KFD70579.1; -; Genomic_DNA.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR GO; GO:0070966; P:nuclear-transcribed mRNA catabolic process, no-go decay; IEA:InterPro.
DR GO; GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IEA:InterPro.
DR GO; GO:0071025; P:RNA surveillance; IEA:InterPro.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR004405; Transl-rel_pelota.
DR PANTHER; PTHR10853; PELOTA; 1.
DR PANTHER; PTHR10853:SF0; PROTEIN PELOTA HOMOLOG; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
FT DOMAIN 1294..1486
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1612..1770
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2553..2577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2818..2842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2842 AA; 319698 MW; 0C0B991F74F065CB CRC64;
MKGLCSQKPL EWVSSLIARF EEQLPVKTGP LKNETRLLLE QSQACLVNVS KLKFSMVVGG
LIRVLQMVNS MKTCSEQDLF DSQCFILDTL EQCLAGPQDT SSHLDEENNV KLIVQEMCKF
IQIPVDSNQA IQLKGKASKV LYGLSISSFD LIFSRIVFRL KSMSTDTSSA SLSGDVGLGI
GDAVDIELMQ YIHFDLKALI KLLREISYYR PFRKDNNQVL FNSIENAIWN WMDTYPDRYY
DLQITQNREL DECCYRLFDQ LDSFAAESSK RRSSIWPLQM MLLILCPKTF QELRSIKPNA
PCQLRLEKQK LFLQSIEKTL TMGHAHATKH HLLAAACVAG AKLCKAATYI NVADPDNVFF
SILQTMIDEV KSYLFSATKP LFKNLPSVQE LDVMIECFVA LFRLNHNNEV FRVCLDTHAT
IPHRLVLVMA LYRIAVQTRL PWWPKIDLVY SRSEELVQIF NETLNNVCQG ARNAFVLPSS
TSIAISSHMP LRVTQSLHKM TGKLKDKSIT VCSGLSYPGS IAGYAINLSS AEDATSCRQL
LFWLIRLMCI EPKLFLRPAQ GAASAAISVV REQSVEQRSS CTSEVVNGLV SLIVSSSEMP
ELAQEAMEAV LCLHQPENVE LWQLASLSAT IQSLWHISSQ LLFHVCQKLL HFQLGNFSEV
LRWLRQLLVY RNLFLMNHRE IANYGSGDLL CKQAAEKLET VCFVYLWSLD NDAAITALSL
FRVMCEEAEI RCSSDELPAE YVHHAELANA TNLPTVGRAV LQKSINSYLK KLTVPTTGCR
QAWEDTYRYW VAFTKFLKSF PKSKFDESLQ MVEMLTKQMM DRNSTRGSEL NLQMVIKLWA
NMTGFLCATG GVVLQTSACV NSDLYAPVTK LNPIVDNEKN VHSVEFSLPN QDILCSVASF
LNQLLSLLLI PSQKLEASIL RHVKELCSYE LHVSLIGHFF EQIHSVTNRF SDDTGQVNIC
SQNTDFVEHV VYVMKNVLLN CSKLDARTTQ LVCIEPIMLN LCKYAHVLEV GSQAFTIKSK
ICQLIKVVMT HRDHVVFQSE IRFRNKLVDL IASWIICNPS SCSAAVIMNC SPLFSSEAVV
TLRELNLCCM IALATLVKDL PLQSEEPTNN VDTLGMNKSQ LFQKFFNLFM NLLNDCTLYE
NMATNARSSY KVETVPLPKA ACDSVVIEGN YPNSSPSCVS TSSSATARRL DENKDRMDRL
RSATIQAMSG LLAANIDIGL MHAIGMGYHK DTRARVAFVE VLTKVLQEGT EFETLNETVM
ADRFDELVKL TTIITSDGEL PIVNALAHVV QTEHMDGLAR LLTTLFASKN LLHELLWKLF
TKEVELAEAP TTLFRGNTLA SKVMGCCFKL YGYGYLRSLL REFVCATTQN ADKCYEVDQS
RLEEGANLAE NTANLIDLVE DILNLILKSA DQFPVQLKSM LNVLFHVVNA RFPNTGLLAV
GMIVFLRFFN PAIVSPVEYG ITDVYPSAST KRGLMLVSKI LQQIANQAQN VKENCLHPFS
NFIHDKYEIV KQFSTSIAID FKIHREELST SSFAYGVDTP AYALHFLLWR YQDRIGEFFN
TFRSHDKVSR RLAALLAQLG PPDGDLEAKQ WVNVGFTCSR FEELMEKQSA ADKDEYKFVK
ETNIFYQYGT SRAGNPVFYF IANRFKTGEV NGNMLIYHVI LTLKQFSNQP CELVVDLTHT
NTENRFRTDL LSKWFVVISQ SVQQSVAAVY LCNCNSWVRE YTRFHDRLFS TLKGNRKLHF
LDSVRRLNEF VCPENQRLPT ATLLLDEDAK TFNNVVRLSH KSIKCSVKIG PMALQIVSLE
KQKVLGHLVN LNDVCVVDEN SITVTILNEP SPLSLIHSEC EQIASSVASI RSKYELSQPD
QSPVHTKIRA KDVPGTLLNM ALLNLGSTDP SLRTAAYNLL CALAATFNFR MEGQLLETKG
LLIPANNTIF IKTVSQKLAV NETHLTLEFL QECIQGFRQS SIEIKHLCLE YITPWLANLP
RFCRPTLGDE SRRQAVSRVL DKLITLTIEE FEMYPSIQAK IWGNVGQVSE LLDLILDRFI
RQSIAGGLGS VQAEVLADTA VTLAAANTEL VSDILIRRLM HLLEKSCLNP QTCLEEHILW
DDIALLARYL LFLSFNNCLD VITHLPVLFH FVIVLVNTGP LALRASVHGL VVNIIHSLCT
CPSSFTEGTK TNLRLALTEF FLPKFYRLFG VSNLTVKTVA ATAFRISPRM SLPVHASSEY
YASGIPVPRQ DRLTLANLEV ITDSLIELIE TCNQDIKNRD MIQEWAKLAH HFSLRFNPAL
QGRALIVYSC LSKTTEEVTV KQLLNLLLQF VKRRDDSNLL SAVLMALRRL TPSLLSEHCN
MFPSLFWISI IILQFEDPML YEHGLALLEQ VIMTLTSSNV FEYGSFEKIM MDARPPLEWE
FKAMDQQVGI SFKHHFHFAL VSYLLKGYRH PSQSVAPRTM RLLTLLLSTV ARCTKRERYE
VTMDTVAYLI ALLPVSEEVR LRCPLHSSTI KALSLREASE CSAKVSNSCQ ENVDSPCDAA
CKQQVSSLNG THPPYHGTLG AWKLRHQQRS CDNLDAASPS TSTAVNPRQS TGYSSQRSYS
LPLGSTIVCP VKESSIVNRL YNYDKSLNWI HSAPQAAYTV GLSPRPSEPR SSFRENLLLD
PEVLCEPSIQ VLTLTVLSTL VRYSTDDKEM RILFEYLAEA SVVFPSIFPV MYYGTVFISA
SHSLLDQKIT QVLQVSHDAA LLRAVLHIIQ NMIPNDGSTV AYKKHHFTLL QNYGFGGLWR
FAGPFPLKPT SPLAISPETL TCLERIIGNL GEVPPLTPPP LTPCKTNSGS ALRFDALESQ
NSVSGDKRNS IVERLEHSSQ AS
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