ID A0A085NQ66_9BILA Unreviewed; 570 AA.
AC A0A085NQ66;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Gelsolin repeat protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=M513_05326 {ECO:0000313|EMBL:KFD53820.1}, M514_05326
GN {ECO:0000313|EMBL:KFD71612.1};
OS Trichuris suis (pig whipworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichuridae; Trichuris.
OX NCBI_TaxID=68888 {ECO:0000313|EMBL:KFD71612.1};
RN [1] {ECO:0000313|EMBL:KFD71612.1, ECO:0000313|Proteomes:UP000030764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCEP-RM93F {ECO:0000313|EMBL:KFD71612.1}, and DCEP-RM93M
RC {ECO:0000313|EMBL:KFD53820.1};
RX PubMed=24929829; DOI=10.1038/ng.3012;
RA Jex A.R., Nejsum P., Schwarz E.M., Hu L., Young N.D., Hall R.S.,
RA Korhonen P.K., Liao S., Thamsborg S., Xia J., Xu P., Wang S.,
RA Scheerlinck J.P., Hofmann A., Sternberg P.W., Wang J., Gasser R.B.;
RT "Genome and transcriptome of the porcine whipworm Trichuris suis.";
RL Nat. Genet. 46:701-706(2014).
CC -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC {ECO:0000256|ARBA:ARBA00008418}.
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DR EMBL; KL363213; KFD53820.1; -; Genomic_DNA.
DR EMBL; KL367481; KFD71612.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A085NQ66; -.
DR Proteomes; UP000030758; Unassembled WGS sequence.
DR Proteomes; UP000030764; Unassembled WGS sequence.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR CDD; cd11290; gelsolin_S1_like; 1.
DR CDD; cd11291; gelsolin_S6_like; 1.
DR Gene3D; 3.40.20.10; Severin; 4.
DR Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR007122; Villin/Gelsolin.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR PANTHER; PTHR11977:SF85; HP DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11977; VILLIN; 1.
DR Pfam; PF00626; Gelsolin; 4.
DR Pfam; PF02209; VHP; 1.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 4.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 4.
DR SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 26..104
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 145..194
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 260..324
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 384..459
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 526..559
FT /note="HP"
FT /evidence="ECO:0000259|Pfam:PF02209"
SQ SEQUENCE 570 AA; 64876 MW; 8E90832F59F612D5 CRC64;
MSPVCDAAFV DAGKKPGLEI WRIEQFDVVP LPRSDYGFFY EGDAYLVLHT SEQFRHYIHF
WLGSKCTQDE FGTAAIKAVE LDDLFGGEPV QMREVQGYES DRFLSYFKRG VSYLEGGVKS
GFKRGGLSPN KRLFRIKGKR RCRMQQVCLS AESLNNGDVF VLDAIENIYV WCGRDCSRIE
RTKGIEFARE VRDFAHHGKA LIHILEAGVD NCKHFFEQLG ASPNYVVTKT DTKENDLAHE
HEQNFLTKLF RVSDATGETQ IKEIDCFILD LGKSAVFVWI GKRCTDSEKK AVWKMANDFL
KARSYPTWVN IIRVNENAEP PLFRSAFLWP SEKAFHGMNV VVADDNLASK EKRAIAALAA
SAEEENKFPI RLFHCSDESG TLTVEEMVNF TQEDLYEDDV MILDTLDQIF IWIGKYANES
EKQAAKRNAT EYVNRDPTSR SGDTIKITVV QQGLETPTFT SCFPYWDKAK WQSVVTDKDI
GDFIFSENQN VKRDQFGTEK QDLPSSVETL SHDDGGLETL RKEQSLSDSE FATLFHMTRG
QFEELPLYSK LAKKKAAGLS VFPSSYITHL
//
