ID A0A087A9W5_9BIFI Unreviewed; 1196 AA.
AC A0A087A9W5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=BCAL_0822 {ECO:0000313|EMBL:KFI55565.1};
OS Bifidobacterium callitrichos DSM 23973.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=1437609 {ECO:0000313|EMBL:KFI55565.1, ECO:0000313|Proteomes:UP000029072};
RN [1] {ECO:0000313|EMBL:KFI55565.1, ECO:0000313|Proteomes:UP000029072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23973 {ECO:0000313|EMBL:KFI55565.1,
RC ECO:0000313|Proteomes:UP000029072};
RA Ventura M., Milani C., Lugli G.A.;
RT "Genomics of Bifidobacteria.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFI55565.1}.
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DR EMBL; JGYS01000005; KFI55565.1; -; Genomic_DNA.
DR RefSeq; WP_052119092.1; NZ_JGYS01000005.1.
DR AlphaFoldDB; A0A087A9W5; -.
DR STRING; 1437609.BCAL_0822; -.
DR eggNOG; COG1197; Bacteria.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000029072; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 655..816
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 841..991
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1196 AA; 131693 MW; 92B4FEC1421B43A9 CRC64;
MAAESGITPE QTLVNGSLAG ILESLNRDPV FGKVVSGGID ETDDIDGSIV VGAPEGVRPA
IAAAIAQGGA VKPRPVVLVV ASGREAEEMV GSLRSWYDGD PNDIAQLEAW ETLPHERLSP
RADTVAGRMA VFRRLRHPSD TDPMFGPVRI LVMPVRSLIQ PVVSGLADVE PLVFTRGNDL
PLDEAAKRLI ENAYTRVDLV MDRGEFAVRG GILDVFPPTA PHPVRIEFFG DEIDQIKEFH
ASDQRTYGDG LKTIWATPCR ELQLTDKVRA RAKALIGSIP NAEDMLESIA NAIPVEGMES
LMPALIDDME PVSAMLPGTA VILLSDPEKL RRAADDLTKT ANEFLAASWH VAASGHGAGA
PISFDQASFL DFEETVRSLN LTGHDVIDLT SFTVDSTRPG HVQIDAKNPA EYRGDESKAA
AGIEGLIDEG LKVVITAGAK GTLARLKRAI NETGITRFET IRSQALDGFV DRSAGVALLT
ERDLTGRTSA VGVAKTPKRR RKAIDLMELK AGDYVVHEQH GIGRFVEMRQ RTIGTGANRT
TREYLVIEYA PSKRGAPPDK LFIPTDQLDQ VSKYIGAETP KLNKLGGSDW AATKAKARKH
VQEIADDLVK LYSARQRTPG FAFSPDTPWQ KELEDAFPYQ ETPDQLTTID EVKADMEKPR
PMDRLICGDV GFGKTEIAVR AAFKAIQDGK QVAVLVPTTL LVQQHYETFT ERYEGFPVTV
RAMSRFQKPK EIQETIDGLA SGGVDIVIGT HKLLNPKIKF KDLGLVIIDE EQRFGVEHKE
TLKALRTNVD VLSLSATPIP RTLEMAVTGI REMSTLATPP EDRLPVLTYV GAYEDAQVTA
AIRRELLRGG QVFYVHNRVE DIARVADRIH TLVPEARVSV AHGKMGEKQL DQVIRDFWHR
DIDVLVCTTI IETGLDISNA NTLIVDHADR FGLSQLHQLR GRVGRGRERA YAYFLYDPSR
TLTQQSHDRL ATIAQNTALG SGFDVAMKDL ELRGTGNLLG DQQSGHIEGV GFDLYVRMVS
EAVEAYKEPD KASEPLNVSI DLPVEASIPV DYIDSDKLRL EAYRKLAAAR DEQDLKELAE
ELTDRYGPLP EEFEMLFGVA RLKFKARKLG ISEILAQSNR LRVGRVDPPE SILMRMSRIY
KGFQYRPVTH QMIIPTPFAG TLGGKPMPGE QVMDWVSDLL NDLAWTPASS KRQSRL
//
