ID A0A087G2F8_ARAAL Unreviewed; 1133 AA.
AC A0A087G2F8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=AALP_AAs46094U000200 {ECO:0000313|EMBL:KFK24060.1};
OS Arabis alpina (Alpine rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK24060.1, ECO:0000313|Proteomes:UP000029120};
RN [1] {ECO:0000313|Proteomes:UP000029120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT "Genome expansion of Arabis alpina linked with retrotransposition and
RT reduced symmetric DNA methylation.";
RL Nat. Plants 1:14023-14023(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; KL972681; KFK24060.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087G2F8; -.
DR EnsemblPlants; KFK24060; KFK24060; AALP_AAs46094U000200.
DR Gramene; KFK24060; KFK24060; AALP_AAs46094U000200.
DR eggNOG; KOG1075; Eukaryota.
DR OrthoDB; 683341at2759; -.
DR Proteomes; UP000029120; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd06222; RNase_H_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044730; RNase_H-like_dom_plant.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF565; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13456; RVT_3; 1.
DR Pfam; PF01582; TIR; 2.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029120}.
FT DOMAIN 108..276
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT DOMAIN 387..553
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1133 AA; 129463 MW; AA17687BF66C245E CRC64;
MANRLSNPKN TSPSRKGFIN CFTDAAWLAS SNQAGIGWTI ELDNGPSVIH SSPIDNVKSV
LAAEALAMRS ALVKARFLRI PKIIVKSDSQ KLINAINIRS SIVEIHGIFE DCRICSDFFA
EIEFVFIPRG ENFIADGGGI NVYVDQDDKL RGVDPNNSLV KKIEESKIAL AIFSSKYTES
SWCLDELVKI KERVEEGKLV VFPIFYKMNP SEVKGLEGAF GINLWNQVKH TSEFDKLKKW
KEALDFVSHK AGLVWTEDSD ENEFITSIEE EVKRMTCISE ELELSKPDKD EFMDTRFSKS
EELKRVDNET GVTLLDANPE EAERIQGHEA KMYSNLRIDD GPHRRNDDIS HGEANFDATL
NLQNGVESKH GKVKPSSTIA RYEKDTSTHQ VFMNFRGEDV GFSFVSHLVS ALKREGINIF
IDKDERKSKD IGQIFKKIED SKIAVVVFSG TYSESTWCLE ELMKIKECMD QGKLKVIPIS
YKVEPLQLKE LNGGFGNKLW NLWKLHRDHH IIRWKEALES VSSLDAMTRF WLKEDNSEGA
FVASIVEEVK KVLAEVSLQQ GQNLGTTGFS VRREEYPETF PNKDQLFGIE QRMEQLEHKL
EFDCDETRVI GVVGMPGIGK TTLTMMLLEK WNCKFVRCVP LLEVCKKSKD YGLVWLRTTL
LKVLLGGEIP VINDETTHES VKNALLQTKV FIVLDDVSDK KQLEFLLGDL KWVKKGSKIV
ITTCDKSLMK GLADDTYLVP QMNNEEAFQL FSSLALDDQI GCPPKTLADN AGGNPLALKL
MAIEYRGKDK PQWENVFIQN VFKHYFDQLN EQQKDVFLDI ASFFKSEDEY FVRSIMDSGD
PDTTDAVSEV TDLVNKFLIT ISNSRIEMND LVYTFGKQLG SPGRHKLWKY KDIINKLGKQ
GKIGFVLEVL IGTCFPGWKV PAWFSYRASG SMLKQNLPSH WCDNRDLDDA FLTETSNDQE
EMNDLVYTFE KDLGSPEQYM RLNYKNITNK LKKMEKAEAN NVRGIILDMF EVTKSIALER
VIFTSMSNLR YLKIYDSCCP RHCKPDCELY FPDGLAFPLE DVRYLHWLKF PLRELPSDFR
PENLVALRLP YSKIERVWEG LKETPSLRWN FNQGTSSDNQ EPPKTCLVEH EKL
//
