ID   A0A087HE08_ARAAL        Unreviewed;       965 AA.
AC   A0A087HE08;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN   OrderedLocusNames=AALP_Aa3g363800 {ECO:0000313|EMBL:KFK40360.1};
OS   Arabis alpina (Alpine rock-cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX   NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK40360.1, ECO:0000313|Proteomes:UP000029120};
RN   [1] {ECO:0000313|Proteomes:UP000029120}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX   PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA   Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA   Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA   Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA   Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA   Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA   Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA   Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA   Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT   "Genome expansion of Arabis alpina linked with retrotransposition and
RT   reduced symmetric DNA methylation.";
RL   Nat. Plants 1:14023-14023(2015).
CC   -!- FUNCTION: Probably involved in the RNA silencing pathway and required
CC       for the generation of small interfering RNAs (siRNAs).
CC       {ECO:0000256|RuleBase:RU363098}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC         ECO:0000256|RuleBase:RU363098};
CC   -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC       ECO:0000256|RuleBase:RU363098}.
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DR   EMBL; CM002871; KFK40360.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087HE08; -.
DR   EnsemblPlants; KFK40360; KFK40360; AALP_AA3G363800.
DR   Gramene; KFK40360; KFK40360; AALP_AA3G363800.
DR   OMA; DSPIQPM; -.
DR   Proteomes; UP000029120; Chromosome 3.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF55; RNA-DIRECTED RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029120};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU363098};
KW   RNA-mediated gene silencing {ECO:0000256|RuleBase:RU363098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
SQ   SEQUENCE   965 AA;  109585 MW;  C2D089A6619D961D CRC64;
     MENKTTSIVL PGQIETILEE IYKKHNTGPI NDETRKRLSL VCEELASDTL QKILNSKHVF
     SLDGFIKYFL DQSSGKFPAP AQSPPCSSAA QYRALREEIC VDLEPLETQG NGGSLHCPQL
     FALAELEFKK MFLFLSYIPG QDLSKVISVD EIRQLKDLPM VAYEAAVWNR FGRHFCSQTD
     RRVVLEWDSG KTRYYQCHVA LDGSYTFKGP LLEHTGTHLH KVLGDENVLT VKFADVPKYS
     SIDCNDRDLI YKRVVKNGIM IGLRRYQFFV FKDGGKEEKK KDFATKGVKC YFIRTDSTSS
     NDMGNHYIFS GKSIHEARMH FMHVHTLKSL AKYMARFSLI LSKTKTLDVY GTGINFEIID
     DIHCHDQYGN VVLDKDNKPR IHSDGTGYIS EDLARLCPTN IFKGKCFGRL DNIQEACGQE
     PPLLIQFRMF HDGSAIKGTF LLNKKLPPRT VQVRPSMIKV FEDTDLSNFS TFNSLEVVNT
     SNPPKRITRL SRNLIALLSY GGVPDDFFMN ILLNTLEESK TIFYNKRSAL KTALKYGEMD
     DYNAAEMILV GIPLDEPHLK SHLSTLLKTE KNSLKEGKLP VSESYYLMGT VDPTGELKED
     EVCVILESGQ ISGDVLVYRN PGLHFGDIHV LKATYVKALE EYVGNSKYAV FFPQKGPRSL
     GDEIAGGDFD GDLYFISRNP ELLAHFRPSE PWVSLSTPSQ SISTREPCQF SPEDLENELF
     DMFLKSRFYS SVIGIAADCW LTIMDRFLVL GNDGAEEKVE MRMKMLQLID IYYDALDAPK
     KGAKVDLPSE LRPDIFPHYM ERDKTFKSSS ILGLIYDFVE SQKTEQPSLP SAEITKLPCF
     EDEPVSKSHM EKYTQWYADY RADMTEALNT DVSNKDESAN EVIQRYKQEF YGAAGFEDSE
     KSLEELYPQA IALYNIVYKH AIKAGVSRCD FVWKVAGPVL CRLYLKKTKE KIVMGSVSVL
     KDLWG
//