ID   A0A087HLY3_ARAAL        Unreviewed;       497 AA.
AC   A0A087HLY3;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
GN   OrderedLocusNames=AALP_Aa1g084600 {ECO:0000313|EMBL:KFK43135.1};
OS   Arabis alpina (Alpine rock-cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX   NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK43135.1, ECO:0000313|Proteomes:UP000029120};
RN   [1] {ECO:0000313|Proteomes:UP000029120}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX   PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA   Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA   Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA   Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA   Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA   Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA   Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA   Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA   Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT   "Genome expansion of Arabis alpina linked with retrotransposition and
RT   reduced symmetric DNA methylation.";
RL   Nat. Plants 1:14023-14023(2015).
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447}.
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DR   EMBL; CM002869; KFK43135.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087HLY3; -.
DR   EnsemblPlants; KFK43135; KFK43135; AALP_AA1G084600.
DR   Gramene; KFK43135; KFK43135; AALP_AA1G084600.
DR   eggNOG; KOG1339; Eukaryota.
DR   OMA; KPRGYLQ; -.
DR   OrthoDB; 663640at2759; -.
DR   Proteomes; UP000029120; Chromosome 1.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd05476; pepsin_A_like_plant; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR034161; Pepsin-like_plant.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR032799; TAXi_C.
DR   InterPro; IPR032861; TAXi_N.
DR   PANTHER; PTHR13683; ASPARTYL PROTEASES; 1.
DR   PANTHER; PTHR13683:SF856; EUKARYOTIC ASPARTYL PROTEASE FAMILY PROTEIN; 1.
DR   Pfam; PF14541; TAXi_C; 1.
DR   Pfam; PF14543; TAXi_N; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022750};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|ARBA:ARBA00022750};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029120};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          84..436
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        102
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        318
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
SQ   SEQUENCE   497 AA;  54202 MW;  36BDC07C1AB541CB CRC64;
     MAVDSPTGVI IAAVFLHAAT TMVFGSSDAV LKLERLIPPS HELGLNQLRA FDSARHGRLL
     QSPVGGVVNF PVNGVADPFL VGLYYTKVKL GTPPREFNVQ IDTGSDVLWV SCTSCNGCPK
     TSELQIQLSF FDPGLSSSAS MVSCSDRRCY SNFETESVCS PDNLCSYTFK YGDGSGTSGY
     YLSDFMSFDT VITSTLAINS SAPFIFGCSN LQTGDLQRPR RAVDGIFGLG QGRLSVISQL
     AQQGLAPRVF SHCLKGDKNG GGLMVLGQIK RPDTVYTPLV SSQPHYNVNL QSIAVNGQIL
     PIDPSVFTIA TGDGTIIDTG TTLAYLPDEA YGPFVQAISN AVSQYGRPIS YESYQCYDIS
     SGAVDIFPEV TLSFAGGASM VLKPRGYLQI FSNSGSSIWC IGFQRMSHRR ITILGDLVLK
     DKVVVYDLVR QRIGWAEYDC SLEVNVSATR GGRRENFINT GQWRESSSEK GFYRRYYLLT
     VAFLFHLLLL SRSFSFL
//