ID   A0A087R482_APTFO        Unreviewed;      1105 AA.
AC   A0A087R482;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
DE   Flags: Fragment;
GN   ORFNames=AS27_14933 {ECO:0000313|EMBL:KFM08286.1};
OS   Aptenodytes forsteri (Emperor penguin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC   Aptenodytes.
OX   NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM08286.1, ECO:0000313|Proteomes:UP000053286};
RN   [1] {ECO:0000313|EMBL:KFM08286.1, ECO:0000313|Proteomes:UP000053286}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM08286.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361199};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR   EMBL; KL226089; KFM08286.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087R482; -.
DR   STRING; 9233.A0A087R482; -.
DR   Proteomes; UP000053286; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd11667; GH38N_Man2A2; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR   PANTHER; PTHR11607:SF57; ALPHA-MANNOSIDASE 2X; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW   Hydrolase {ECO:0000256|RuleBase:RU361199};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361199};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT   DOMAIN          459..545
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFM08286.1"
FT   NON_TER         1105
FT                   /evidence="ECO:0000313|EMBL:KFM08286.1"
SQ   SEQUENCE   1105 AA;  124946 MW;  68C56D9BE5AF405F CRC64;
     PQSQISVLQN RIEQLEQLLE ENHEIISHIK DSVLELTAHA EGQPALPHHT PNGSWVLPPE
     SRPSFLSVSP QDCQFALGGK GQSPDLQMLA VYSLLPFDNQ DGGVWKQGFD ITYEPNEWDA
     EPLQVFVVPH SHNDPGWIKT FDKYYYDQTQ HILNSMVLKM QEDPRRRFIW SEISFFSKWW
     DNISAQKRAA VRRLVGNGQL EMVTGGWVMP DEANSHYFAM IDQLIEGHQW LEKNIGVTPR
     SGWAVDPFGH SSTMPYLLKR SNLTGMLIQR VHYAIKKHFA ATQNLEFMWR QTWDPDASTD
     IFCHMMPFYS YDVPHTCGPD PKICCQFDFK RLPGGRINCP WKVPPRAITD ANVAERAQLL
     LDQYRKKSKL YRSKVLLVPL GDDFRYDKPQ EWDAQFLNYQ RIFDFLNSRP NLHVQAQFGT
     LSDYFDALYK KVGIVPGMKP PGFPVLSGDF FSYADREDHY WTGYYTSRPF YKSLDRVLEA
     HLRGAEILYS LALAHARHAG TDGRYPISDY ALLSNARRNL GLFQHHDAIT GTAKEAVAGG
     LLRSLTNLKR VIINAAHYLV LGDKDAYRHD PAAPFLGTDD TRPNQDSLPE RTVVKLDASP
     RFLVVFNPLE QERLSVLPVL VDSPHVCVLS EEGQPLPSQL SAHWGSATDM VPDVYQVSVL
     ARLPALGLRV LQLHKSFDSH TTLKSSVRLY LHGRDLHVRK QEAVPVHVFP ATADDFCLEN
     QHLQACFSGR SGLLQASARS IRRTGEEWEQ RVSSEFLIYG TRTSKDKSGA YLFLPDGEAK
     PYTPKDPPVV RVTEGPLFSE VTSYYQHVQT VVRLYNVPGV EGLSLDVSCL VDIRDHINKE
     LALRFSTDIE SDDTFFTDLN GFQIQPRRYQ QKLPLQANFY PMPTMAYIQD MQSRLTLHTA
     QALGVSSLSS GQLEVILDRR LMQDDNRGLG QGLKDNKRTC NRFRLLLERR ATANKDGRPI
     SFPSLLSHIT SMHLNAEALV MPVAQEKPAP PALRSFMPLS TTLPCDFHIL NLRMLQAEDD
     SLPSAEAALI LHRKGFDCSL EAKNLGFNCT TSQGKLALGS LFQGLELGSL QPTSLTLMYP
     LGTASNSTNI CLDPMEIATF RIRLG
//