ID A0A087V5Z3_BALRE Unreviewed; 257 AA.
AC A0A087V5Z3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
GN ORFNames=N312_01435 {ECO:0000313|EMBL:KFO08035.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO08035.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO08035.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO08035.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
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DR EMBL; KL481093; KFO08035.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087V5Z3; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU365037}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU365037"
FT CHAIN 19..257
FT /note="Neurotrophin-3"
FT /evidence="ECO:0000256|RuleBase:RU365037"
FT /id="PRO_5001831167"
FT DOMAIN 144..249
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 152..217
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 195..246
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 205..248
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
SQ SEQUENCE 257 AA; 29591 MW; B31584A0666C16CB CRC64;
MSILFYVIFL AYLRGIQSTN MDQRSLPEDS INSLIIKLIQ ADILKNKLSK QMVDIKENYQ
NTVQKADTQQ DMEGDENVKS DFQPVISMDT DLLRQQRRYN SPRVLLSGNT PLEPPPLYLM
EDYIGNSVVV NRTSRRKRYA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK
TGNSPVKQYF YETRCKEAKP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI
RIDTSCVCAL SRKIGRT
//
