ID A0A087VZW6_ECHMU Unreviewed; 457 AA.
AC A0A087VZW6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Otopetrin {ECO:0000313|EMBL:CDI97922.1};
GN ORFNames=EmuJ_000173600 {ECO:0000313|EMBL:CDI97922.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDI97922.1};
RN [1] {ECO:0000313|EMBL:CDI97922.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDI97922.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the otopetrin family.
CC {ECO:0000256|ARBA:ARBA00006513}.
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DR EMBL; LN902846; CDI97922.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087VZW6; -.
DR STRING; 6211.A0A087VZW6; -.
DR eggNOG; KOG4740; Eukaryota.
DR OMA; ACAIFYK; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015252; F:proton channel activity; IEA:InterPro.
DR InterPro; IPR004878; Otopetrin.
DR PANTHER; PTHR21522:SF32; OTOPETRIN-LIKE A, ISOFORM C; 1.
DR PANTHER; PTHR21522; PROTON CHANNEL OTOP; 1.
DR Pfam; PF03189; Otopetrin; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 25..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 457 AA; 51786 MW; EF7852567FCFCE86 CRC64;
MFGDRTTMDR KRNPPLIECE QGNNLYLRLG AVVFGFGVMI MDGFRVADQF DSLNAALSCH
SAFWIPVNVV HSFYIFWQTY FLFKHHHVVF NVKKFFVRFI LAHMTVVNLG QWMGTVVQEV
MISDKEERNT SALNISALSA LIVSKNLNLT TNLYAQCKSQ VGIFASYLIP CGVEYSLIAC
AIFYKMFRRV GHITRSEVEP QCVRSSSTAD EGARSAYECL VSRNNPTECQ HAHKGLFAGL
LLVMTTLVAL ALFYTHLQRS SQVEALTLFQ GTYIVLLSIG ILAVSIALFQ VRVLGARQMS
EDSAFDDYLL LIGLMGILFY NMFLLAPAME EGESYKIART MFISKSVLEI LQALIQVFFI
LEASRSQASN MRQVIEKPGR TVITFLLILN LAMWMVTTFG LKHAEGYSIH RTHYSDIAWK
IITHLSMPLI VFFRFHSTVC LADVWSNAYR AHKPTFV
//
