ID A0A087X5F9_POEFO Unreviewed; 1939 AA.
AC A0A087X5F9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Myosin heavy chain, fast skeletal muscle {ECO:0000313|Ensembl:ENSPFOP00000001012.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000001012.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000001012.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AYCK01008259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01008260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000001012; -.
DR Ensembl; ENSPFOT00000001014.2; ENSPFOP00000001012.2; ENSPFOG00000000249.2.
DR eggNOG; KOG0161; Eukaryota.
DR GeneTree; ENSGT00940000162888; -.
DR OMA; CCELISH; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 6.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF44; MYOSIN-13; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..781
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 658..680
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1883..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 845..1272
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1301..1335
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1939 AA; 221801 MW; 1CD208D95B59E02E CRC64;
MSTDAEMEAY GPAAIYLRKP ERERIEAQAA PFDAKTAYFV VDPDEMYLKG KLVKKEGGKA
TVEIEGGKTV TVKEDDIHPR NPPKFDKIED MAMMTHLNEP CVLYNLKDRF ASWMIYTYSG
LFCVVVNPYK WLPVYDAVVV GAYRGKKRIE APPHIFSVSD NAYQFMLTDR ENQSILITGE
SGAGKTVNTK RVIQYFATIA MTGSKKAEPV AGKMQGSLED QIIAANPLLE AYGNAKTVRN
DNSSRFGKFI RIHFGTSGKL ASADIETYLL EKSRVTFQLS AERSYHIFYQ LMTGHKPELL
EALLITTNPY DYHMISQGEV TVKSINDVEE FIATDTAIDI LGFTADEKIN IYKLTGAVMH
HGNMKFKQKQ REEQAEPDGT EEVADKIAYL LGLNSADMLK ALCYPRVKVG NEMVTKGQTV
PQVNNAVSAL CKSVYEKMFL WMVIRINEML DTKQSRAFFI GVLDIAGFEI FDFNSLEQLC
INFTNEKLQQ FFNHHMFVLE QEEYKKEGIE WEFIDFGMDL AACIELIEKP MGIFSILEEE
CMFPKASDTT FKNKLIDQHL GKSKAYEKPK PGKGKAEAHF SLVHYAGTVD YNITGWLDKN
KDPLNDSVVQ LYQKSSNKLL CLLYVAHASA ESGGGGKKGG KKKGGSFQTV SALFRENLGK
LMTNLRSTHP HFVRCLIPNE SKTPGLMENF LVIHQLRCNG VLEGIRICRK GFPSRILYGD
FKQRYKVLNA SVIPEGQFID NKKASEKLLG SIDVDHTQYK FGHTKVFFKA GLLGTLEEMR
DEKLAELVTM TQALCRGYVM RKEFVKMMER REAIYSIQYN IRSFMNVKNW PWMTLYFKIK
PLLKSAETEK ELQNMKENYE KMKTDLAAAL AKKKELEEKM VSMLQEKNDL QLQVAAEVEN
LSDAEERCEG LIKSKIQLEA KLKETSERLE DEEEINAELT AKKRKLEDEC SELKKDIDDL
ELTLAKVEKE KHATENKVKN LTEEMATQDE AIAKLTKEKK ALQEAHQQTL DDLQAEEDKV
NTLTKAKTKL EQQVDDLEGS LEQEKKLRMD LERAKRKLEG DLKLAQESIM DLENDKQQSD
EKIKKKDFEI SQLLSKIEDE QSLGAQLQKK IKELQARIEE LEEEIEAERS ARAKVEKQRA
DLSRELEEIS ERLEEAGGAT AAQIEMNKKR EAEFQKLRRD LEESTLQHES TAAALRKKQA
DSVAELGEQI DNLQRVKQKL EKEKSEYKME IDDLSSNMEA VAKAKGNLEK MCRTLEDQLS
EIKAKNDENV RQLNDINGQK ARLQTENGEF GRQLEEKEAL VSQLTRGKQA FTQQIEELKR
HIEEEVKAKN ALAHAVQSAR HDCDLLREQF VRELETEVEA ELQRGMSKAN SEVAQWRSKY
ETDAIQRTEE LEEAKKKLAQ RLQEAEESIE AVNSKCASLE KTKQRLQGEV EDLMIDVERA
NSLAANLDKK QRNFDKVLAE WKQKYEESQA ELEGAQKEAR SLSTELFKMK NSYEEALDQL
ETMKRENKNL QQEISDLTEQ IGETGKTIHE LEKAKKTLDS EKSEIQAALE EAEGTLEHEE
AKILRVQLEL NQVKSEIDRK LAEKDEEMEQ IKRNSQRVID SMQSTLDAEV RSRNDALRVK
KKMEGDLNEM EIQLSHANRQ AAEAQKQLRN VQGQLKDAQL HLDDALRGQE DMKEQLAMVE
RRNGLMMAEI EELRAALEQT ERSRKVAEQE LVDASERVGL LHSQNTSLLN TKKKLEADLV
QVQGEVEDAV QEARNAEEKA KKAITDAAMM AEELKKEQDT SGHLERMKKN LEVTVKDLQH
RLDEAENLAM KGGKKQLQKL EQRVRELESE VEGEQRRGAE AVKGVRKYER RVKELTYQTE
EDKKNLVRLQ DLVDKLQLKV KSYKRQAEEA EEQANTHMSR LRKVQHEMEE AQERADIAES
QVNKLRAKSR DAGKSDSAE
//
