ID A0A087X6G8_POEFO Unreviewed; 838 AA.
AC A0A087X6G8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=FYVE, RhoGEF and PH domain containing 1 {ECO:0000313|Ensembl:ENSPFOP00000001371.1};
GN Name=FGD1 {ECO:0000313|Ensembl:ENSPFOP00000001371.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000001371.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000001371.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; AYCK01023113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087X6G8; -.
DR STRING; 48698.ENSPFOP00000001371; -.
DR Ensembl; ENSPFOT00000001374.1; ENSPFOP00000001371.1; ENSPFOG00000001063.1.
DR eggNOG; KOG4424; Eukaryota.
DR GeneTree; ENSGT00940000159438; -.
DR OMA; QQRWMAV; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15741; FYVE_FGD1_2_4; 1.
DR CDD; cd13236; PH2_FGD1-4; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035941; FGD1-4_PH2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF79; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 258..446
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 475..575
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 617..677
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 707..808
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..64
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..132
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 93749 MW; B1800676A239CD25 CRC64;
NDTGPPELPV TTVTAPNRTR PPLLGPKPQD LQQQAGAMRP RLRVPEKSLP PPPPCRPLPA
DPRGAWTPPN QADGTASPTC VLSLIEKFER EQIIVVPDIT GGALCPRPLD PPSPQSSSPP
SSASPAPPQL GGAEPPSDLT EQDDITQGAE TDGKLANRDS GIDSISSPSH SEELCFTGVD
DGGVAYPCSP ALLPRLSSSS STAGEVGEAE EARMGARRKR DFAEEGDSDL EEEAELTLVL
APPKPDRQES VELSVHQRVF NIANELLLTE TAYVSKLHLL DQVFCAHLLE EARCRSSFPC
DVVQGIFSNI CSIYCFHQQF LLPALQKRME EWDSNPRIGD ILQKLAPFLK MYGEYVKNFD
RAMELVNIWM ERSAPFKAIV QEIQREERCG NLTLQHHMLE PVQRIPRYEL LLKDYLNRLP
EDAPDHRDAQ KSLELIATAA EHSNAAIRKM ERMRKLLKVY ELLGGEEDIV NPTNELIKEG
HILKLSNKNG TTQDRYLILF NDRLLYCVPK LRLIGQKYSV RARIDVDGME LKETSSVAVP
SRTFLVSGKQ RSLELQARTE EEKKDWIQAI QATIQRHEQT MESFRHLTCT LRDDESTPPH
SPSCVELGKR APTPIREKEV TLCMKCQEPF NSITKRRHHC KACGHVVCGK CSEFRARLSY
DNNRTNRVCV DCYVTLVGAS PSPGAMSSSS QRRRSILEKQ ASLAAENSVI CSFLHHMEKG
GGRGWQKAWF VIPENEPLVL YVYGAPQDVK AQRSVPLIGF EVSPPESCDR LERRHAFKIS
QSHLTLYFSA EGEELQRRWM DVLSRAGRGE EPLIHLPIVE SVEEEGEELD GETEEENT
//
