ID A0A087XAA3_POEFO Unreviewed; 378 AA.
AC A0A087XAA3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 2-like {ECO:0000313|Ensembl:ENSPFOP00000002706.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000002706.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000002706.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR EMBL; AYCK01012329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01012330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007568141.1; XM_007568079.2.
DR RefSeq; XP_007568142.1; XM_007568080.2.
DR AlphaFoldDB; A0A087XAA3; -.
DR STRING; 48698.ENSPFOP00000002706; -.
DR Ensembl; ENSPFOT00000002710.2; ENSPFOP00000002706.1; ENSPFOG00000002727.2.
DR GeneID; 103149064; -.
DR KEGG; pfor:103149064; -.
DR CTD; 445247; -.
DR eggNOG; KOG3058; Eukaryota.
DR GeneTree; ENSGT00940000157370; -.
DR OrthoDB; 1343173at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF24; PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 2; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 105..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 243..316
FT /note="Sphingomyelin synthase-like"
FT /evidence="ECO:0000259|Pfam:PF14360"
FT REGION 19..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 43358 MW; 6E041904003C5A6A CRC64;
MAASELIEEE EVRIPVEVNV TSSNSPTQIH PQRVANGNPS RHASTLSPPQ DDHDGNDRRG
GLCSLMLIES LNNKLKRRCD YEKICGAKAE SGDSLPSEWW KTGVAFLYAF FNLVFTTVVI
TIVHERVPDK SVSPPLPDKF FDYVDRVPWA FTITETNGLI LVGLWLVQWL LLKHKSIVGR
RCFFLIGTLY MYRCVTMYIT TLPVPGKHMV CAPKLYNDST GKIWRILRLI SGGGLSLTGS
HLMCGDFLYS GHTVMLTLSY LFIQEYSPRW MWWYRWACWI LSASGVVCIL IGHEHYSIDV
VIAYYVTTRV FWWYHTMANN HDLRGASTSC LTRVWWNPVF NFLERNVQTT VPVVFLSPRA
LLSSCKERYH TMGIERDE
//
