ID A0A087XC11_POEFO Unreviewed; 512 AA.
AC A0A087XC11;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Signal transducing adaptor molecule {ECO:0000313|Ensembl:ENSPFOP00000003314.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000003314.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000003314.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}.
CC -!- SIMILARITY: Belongs to the STAM family.
CC {ECO:0000256|ARBA:ARBA00009666}.
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DR EMBL; AYCK01003072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007548578.1; XM_007548516.2.
DR AlphaFoldDB; A0A087XC11; -.
DR STRING; 48698.ENSPFOP00000003314; -.
DR Ensembl; ENSPFOT00000003320.2; ENSPFOP00000003314.2; ENSPFOG00000003200.2.
DR GeneID; 103135679; -.
DR KEGG; pfor:103135679; -.
DR CTD; 8027; -.
DR eggNOG; KOG2199; Eukaryota.
DR GeneTree; ENSGT00940000157171; -.
DR OMA; QVYRDWW; -.
DR OrthoDB; 620063at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd21389; GAT_STAM1; 1.
DR CDD; cd11964; SH3_STAM1; 1.
DR CDD; cd17000; VHS_STAM1; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR047492; GAT_STAM1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035657; STAM1_SH3.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002014; VHS_dom.
DR InterPro; IPR047528; VHS_STAM1.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF2; SIGNAL TRANSDUCING ADAPTER MOLECULE 1; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF02809; UIM; 1.
DR Pfam; PF00790; VHS; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 16..143
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 211..270
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 153..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 55950 MW; 9430F1C5F7307003 CRC64;
MPLFTTNPFD QDVEKATSEM NTAEDWGLIL DICDKIGQSR TGPKECLRSI MRRVNHKDPH
VAMQALTLLG ACVSNCGKIF HLEVCSREFA SEVSNVLNKG HPKVCEKLKA LMVEWAEDFR
NDPQLSLISA MIKNLREQGV TFPAVGSQAA EQAKASPALV AKDPSTTTNK KEEEDLAKAI
ELSLKEQRQQ PQTSLSSLYP STSSLLSTHK SDGRKVRAIY DFEAAEDNEL TFKSGEIITI
LDDSDPNWWK GETYQGVGLF PSNFVTADLT AEPEMMKTEK KTVQFSEDIQ VETIEPEQEP
VYIDEDKMDQ LLQMIQSADP TDNQSDSVEL LQLEGACNQM GPLIDQKLED IDRKHSELSE
LNVKVMEALS LYAKLMNEDP VYAMYAKLQS QQYYMQQPAS AAQQVYPGQP ASGSYAMSGT
GVQGYTVPVE QLPAGAPIPG QPAPGDVHMY MGQPPVYAAA PGAMAPADIQ SYPNPASAAL
CTAPANYSAP SGTSIAPPSD VPQAPYSEKA LL
//
