ID A0A087XJL3_POEFO Unreviewed; 372 AA.
AC A0A087XJL3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Biglycan {ECO:0000256|ARBA:ARBA00017012, ECO:0000256|PIRNR:PIRNR002490};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000005966.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000005966.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in collagen fiber assembly.
CC {ECO:0000256|ARBA:ARBA00002214, ECO:0000256|PIRNR:PIRNR002490,
CC ECO:0000256|RuleBase:RU364096}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|PIRNR:PIRNR002490,
CC ECO:0000256|RuleBase:RU364096}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class I subfamily. {ECO:0000256|ARBA:ARBA00009811,
CC ECO:0000256|PIRNR:PIRNR002490, ECO:0000256|RuleBase:RU364096}.
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DR EMBL; AYCK01012767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01012768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007568980.1; XM_007568918.2.
DR AlphaFoldDB; A0A087XJL3; -.
DR STRING; 48698.ENSPFOP00000005966; -.
DR Ensembl; ENSPFOT00000005975.2; ENSPFOP00000005966.2; ENSPFOG00000005997.2.
DR GeneID; 103149649; -.
DR KEGG; pfor:103149649; -.
DR CTD; 792197; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000155311; -.
DR OMA; GHNNIRM; -.
DR OrthoDB; 3953748at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR016352; SLRP_I_decor/aspor/byglycan.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF11; BIGLYCAN; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01462; LRRNT; 1.
DR PIRSF; PIRSF002490; SLRP_I; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002490-1};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530,
KW ECO:0000256|PIRNR:PIRNR002490};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|PIRNR:PIRNR002490, ECO:0000256|RuleBase:RU364096}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|PIRNR:PIRNR002490,
FT ECO:0000256|RuleBase:RU364096"
FT CHAIN 23..372
FT /note="Biglycan"
FT /evidence="ECO:0000256|PIRNR:PIRNR002490,
FT ECO:0000256|RuleBase:RU364096"
FT /id="PRO_5011022481"
FT DOMAIN 66..98
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DISULFID 67..73
FT /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
FT DISULFID 71..80
FT /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
FT DISULFID 325..358
FT /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
SQ SEQUENCE 372 AA; 42071 MW; 457E838DFFF5D978 CRC64;
MLPHCSLLLL LCAAQLLSSS SALPFEQRGF WDFALDSLED GGMMSMMRDQ NEGSATEEIL
TPDVPMCPFG CHCQLRVVQC SDLGLTEVPR NIPPDTKFLD LQNNRITELK ENDFKGLTNL
YALSVRNNKI SKVHPKTFAP LKHMQKLYFS KNLLAAIPKN LPASLVELRI HENRIKKVAA
GSFSGLGNMH CIEMGANPIQ NSGFEPGAFK GLKLNYLRIS EAKLTGVPKD LPDSLHELHL
DHNQIQAVEL EDLSRYKNLH RLGLGFNHIL NIENGSLSFL PMLRELHLDN NRLTRVPKGL
PNMKYLQVVY LHSNNISQVG VDDFCPRGFG MKRTYYNGIS LFENPVNYWE VQPATFRCVN
DRFAIQFGNY KK
//
