ID   A0A087XJL8_POEFO        Unreviewed;       529 AA.
AC   A0A087XJL8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE            EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000005971.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000005971.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC         Evidence={ECO:0000256|RuleBase:RU362059};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; Single-
CC       pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR   EMBL; AYCK01007153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01007154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01007155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A087XJL8; -.
DR   STRING; 48698.ENSPFOP00000005971; -.
DR   Ensembl; ENSPFOT00000005980.2; ENSPFOP00000005971.2; ENSPFOG00000005934.2.
DR   eggNOG; KOG1192; Eukaryota.
DR   GeneTree; ENSGT00940000164390; -.
DR   OMA; XLISILA; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48043:SF140; UDP-GLUCURONOSYLTRANSFERASE 2A1; 1.
DR   Pfam; PF00201; UDPGT; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU003718}; Membrane {ECO:0000256|RuleBase:RU362059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Signal {ECO:0000256|RuleBase:RU362059};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362059};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362059}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT   CHAIN           22..529
FT                   /note="UDP-glucuronosyltransferase"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT                   /id="PRO_5005106667"
FT   TRANSMEM        492..515
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
SQ   SEQUENCE   529 AA;  60709 MW;  14FE4B0FE02BE96A CRC64;
     MKLHLSVCVL LLLCGTRSSN GGKILVWYTE ASHWINMKPV LETLVDRGHQ VTVLVPSASM
     FMNSSEPSRF QYEPFDVDVS VKDIQKIFDD LLHFSMYEMD FMNPFQIYMK AIDLTKNNMN
     MSLKFLDGVV KSEAMMKKLK EGNYDVLFAD PIYPGYDLTA DILGIPLVLS LRFSLAHHWE
     RMCGQLPAPP SFVPAAMSKL TDKMNFSERL YNVLFYALQD VVITQFMLKD IDKYYSEVKG
     TPVTNCKMLR NVDIWLMRTF WDFDFPRPLL PNFKFVGGIH CKPAKPLPKK IEKFVQSSGD
     AGIIVFSLGS MVKNLTTEKA NMIASALAQL PQKVLWRYSG KIPDTLGSNT KLYDWMPQND
     LLGHPKTKAF ITHGGTNGIY EAIYHGIPMV GIPMFADQPD NMVHMEAKGA AVIQNLNFMT
     TESLRDAIKS VINNKSYKEN VMRLSKIHHD RPMSPRDEAV FWIEFTMRNK GAKHLRVQAH
     ELTWYQYHSL DVLAFLLIID LLLIFILFKS CSFCFKRCWG RKQPKRKAE
//