ID A0A087XQG1_POEFO Unreviewed; 739 AA.
AC A0A087XQG1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Folate hydrolase 1B {ECO:0000313|Ensembl:ENSPFOP00000008014.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000008014.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000008014.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; AYCK01010017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007564170.1; XM_007564108.2.
DR AlphaFoldDB; A0A087XQG1; -.
DR STRING; 48698.ENSPFOP00000008014; -.
DR MEROPS; M28.012; -.
DR Ensembl; ENSPFOT00000008026.1; ENSPFOP00000008014.2; ENSPFOG00000007722.1.
DR GeneID; 103146267; -.
DR KEGG; pfor:103146267; -.
DR CTD; 10003; -.
DR eggNOG; KOG2195; Eukaryota.
DR GeneTree; ENSGT01030000234598; -.
DR OMA; QGSTEWV; -.
DR OrthoDB; 2428249at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF36; GLUTAMATE CARBOXYPEPTIDASE 2; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Dipeptidase {ECO:0000256|ARBA:ARBA00022997};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 7..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 161..249
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 346..473
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 616..735
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 739 AA; 83511 MW; B81917AC4287D6AB CRC64;
MKRESRLVRW IWWTVVVTAL FLLGFCIGWF SKRSKATANN HKTSSKYLVE FLDEMRPDLI
RDHLRKFTRL PHLAGTEQNL KYAEEIMKEW RDFGLDSVEM VPYDILLSYP NKSQPNYISI
VDHSGKEVFN TSLAEPVPQG YEDVSNIVPP YSAYSPKGHP EGDLVYVNYG RTEDFLQLER
EMNISVTGKI VIVRYGKIFR GNKVKNAMSA GAKGVIMFSD PADYWATGVK PYPDGWNLPG
GGAQRGNVLN LNGAGDPLTP GYPAKEYTYR LNPEEGVGLP KIPVHPIGFH DATHLLKNMG
GQIPPNNWKG ALNVSYKTGP GFTGDFKSQK VRMNIYSNNQ VSRIYNVIGK IRGALEPDRY
VILGGHRDAW VFGGIDPMSG AAVVHETVRS AGKLLKRGWR PRRTVVFASW DAEEFGLLGS
TEWAEDNARL LQERAVAYIN ADSAIEGMYT LRVDCTPSLH TLVYDLTKQI SSPEDGEEGV
SLYESWHKRD NWTNDRDAPR ISKLGSGSDF EAYFIRLGIA AGRARYTKNK KTERYSSYPV
YHSVYETFEI VERFYDPTFR RLRAVAQVRG GLIFLLADSQ VLPLDANEYA DSLRKYADSI
AHLAQTHAEL MKTYNVSFES LFSAVKNFTN AAKDFHERLQ TLDKEDPLQV RIMNDQLMYL
ERAFIDPLGL PGRPFYRHVI FAPSSHNKYA GESFPGIYDA LFDIENSADP DKAWREVKRQ
ISIAAFTVHA AAMTLTPPA
//
