ID A0A087Y1A4_POEFO Unreviewed; 689 AA.
AC A0A087Y1A4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=SH2B adaptor protein 2 {ECO:0000313|Ensembl:ENSPFOP00000011807.2};
GN Name=SH2B2 {ECO:0000313|Ensembl:ENSPFOP00000011807.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000011807.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000011807.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SH2B adapter family.
CC {ECO:0000256|ARBA:ARBA00010220}.
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DR EMBL; AYCK01003516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007549581.1; XM_007549519.2.
DR AlphaFoldDB; A0A087Y1A4; -.
DR STRING; 48698.ENSPFOP00000011807; -.
DR Ensembl; ENSPFOT00000011824.2; ENSPFOP00000011807.2; ENSPFOG00000011778.2.
DR GeneID; 103136322; -.
DR KEGG; pfor:103136322; -.
DR CTD; 10603; -.
DR eggNOG; ENOG502QT43; Eukaryota.
DR GeneTree; ENSGT00950000183191; -.
DR OMA; YHRMEGT; -.
DR OrthoDB; 2995825at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01231; PH_SH2B_family; 1.
DR CDD; cd10411; SH2_SH2B2; 1.
DR Gene3D; 6.10.140.110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015012; Phe_ZIP.
DR InterPro; IPR036290; Phe_ZIP_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR030523; SH2B.
DR InterPro; IPR035058; SH2B2_SH2.
DR PANTHER; PTHR10872; SH2B ADAPTER PROTEIN; 1.
DR PANTHER; PTHR10872:SF4; SH2B ADAPTER PROTEIN 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF08916; Phe_ZIP; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF109805; Phenylalanine zipper; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 250..364
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 473..571
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 122..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 689 AA; 73899 MW; DB121A48A70F728A CRC64;
MNGAVLPGSP ELSSSCPLPD WREFCELHAR ASAADFADKF QRFLSENPCY DSPGADASFS
QHFANHFLEC FSAALTQAKE KQASSPGEDG CNAATKYSIV PFLGIQGCPL TYGHDLYQRR
KDTGASSESL DSMDSGGGGM DGGGGGGSTS SRGPQNHKMS VLGQSRSSED VSVSHPKARF
KKGFSLRNMS LCVVDGVKEM WHRRASPEPD APSGARRANG AGGEAGGGEK WSQKLRLPRS
SQGHKAELLE IQREGALRYM VADDTNCMGA AQWQKCRLLL RKTKREDGGE KFLLEFYVPP
KCSKPKVSIP LSAIVEVRTT MPLEMPDKDN TFVLKVENGG EYILETIDSL QKNSWVADIQ
DCIDPGDSGD DIELASCPHG QASKDCSMVA SCSCELLSEG VYRAPERSCP TAADHYSAPS
VRCREPPFTQ HPSHMPLERF LQSPEAQSSN ASAGGGEGTK EPEGDASLAG YPWFHGTLSR
VRAAQLVLAG GARSHGLFVI RQSETRPGEY VLTFNFQGKA KHLRLSVNEN GQCHVHHLWF
HTVTDMLRHF HAHPIPLESG GSADITLRSY VQVQRSSAAD ATVPPVFTPP RDASCRADPV
QPALHPPGTA APAGPSSDGP LSSSTSSSPT ALPSLSRSDP GTGLGGGGLQ SRSNSSERLL
EASSGASEDY HDADGTRRAR AVENQYSFY
//
