ID A0A087Y4B2_POEFO Unreviewed; 1267 AA.
AC A0A087Y4B2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like {ECO:0000313|Ensembl:ENSPFOP00000012865.2};
GN Name=MAGI1 {ECO:0000313|Ensembl:ENSPFOP00000012865.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000012865.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000012865.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; AYCK01009222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01009223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01009224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01009225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087Y4B2; -.
DR STRING; 48698.ENSPFOP00000012865; -.
DR Ensembl; ENSPFOT00000012883.2; ENSPFOP00000012865.2; ENSPFOG00000012659.2.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00940000155820; -.
DR OMA; MGFGFRI; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 6.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 6.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF77; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF16663; MAGI_u1; 1.
DR Pfam; PF16666; MAGI_u5; 1.
DR Pfam; PF00595; PDZ; 5.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 6.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 6.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 6.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT DOMAIN 17..100
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 104..184
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 296..329
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 356..389
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 467..536
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 636..714
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 819..901
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 980..1076
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1130..1212
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 225..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..777
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..963
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1267 AA; 137898 MW; F2B64B5D5901A45F CRC64;
MSKVIQKKNH WITKVNECAV IRDENGELNV ELHGGAENGE FAYIGQIRED AVVYQDGKLS
EGELLLEVEG LSVSGLPLYD IYTVVNCCKG PVRLKTVRQG HKLNKDLKHF LSLRFQKTSP
DHELQKTIRA NLYRHAVPCT TRPPRDGEVP GLDYNFLSVE DFLQLEESGT LLEVGTYEGN
YYGTPKPPRQ PIIGTVTLSD AGSHPSTPKR TKSYHDMQKV HVVPADDDDD DQATEMNNSF
TGNPNDQDES RSGILRPYPV RDNALPCGLN NAATSTAESG QQTLAEPQVS PEDPLGPLPE
NWEMAYTENG ELYFIDHNTK TTSWLDPRCR DKAPRPLEEC DDDEEGIHTE DLESDLELPP
GWERIDDPVY GVYYVDHINR KTQYENPVLE ARRQKILEQQ QPPQPPEEWI EEHSSAAAPL
ASYAPNHLET YRDPQVPPAL PPGPVGVKRG KPFFTRNPAE LKGTFINTKL KKSRRGFGFT
VVGGDEPDEF LQIKSLVLDG PAAVDGKMET GDVIVSVNDT IVLGYTHAQV VKIFQSIPIG
SMVDLSLCRG YPLPFDPDDP NTSLVTSVAI LDKEPIIVNG QETFDAPTNQ AGPINGMREP
RPHSPLAEVA SNGSHGYSSD VVTLASAIAT QPELITIHME KGDKGFGFTI ADSLTGGGQR
VKQIVDYPRC RGLKEGDILM EVNKRNVQNM SHNQVVDLLS KCPRGSEVTM LVQRGVVPAK
RSPKLVHQLE RKDSQSSSQH SVCSHRSAHT DSPSHPPSAM PSEAVVPTPA APTQPLPVLP
PQDPADGTLT LQKKPDPFKI WAQSRSMYES RLPDCQEQDI FLWRKDTGFG FRILGGNEPG
EPIYIGHIVK YGAADEDGRL RSGDELICVD GTAVVGKSHQ LVVQLMQQAA KQGHVNLTVR
RKTAGYGVSK GEGDVPPSPA SSHHSSTQAP SLTEGKRTPQ GSQNSLNTVS SGSGSTSGIG
SGGGGGSGSA VIPASLQPYD VEIQRGENEG FGFVIVSSVS RPDAGTTFAG NACVAMPHKI
GRIIEGSPAD RCGKLKVGDR ILAVNGCSIT NKSHSDIVNL IKEAGNTVSL RIIPGDESSN
ASLLTNAEKI ATITTTHTPQ TTESRNHSKS KGAPPPPPSQ TQMQDAEYYS VDLERDSKGF
GFSLRGGREY NMDLYVLRLA EDGAAVRNGK MRVGDEILEI NGESTKNMKH SRAIELIKNG
GRRARLVLKR GDGSVPEYAM MAPHLAVGTL RNDKMGEPCF YLMGQNQTTT AAVTGTLPHP
GHKTLRK
//
