ID A0A087Y519_POEFO Unreviewed; 369 AA.
AC A0A087Y519;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Ectodysplasin A {ECO:0000313|Ensembl:ENSPFOP00000013122.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000013122.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000013122.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; AYCK01003058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007548541.1; XM_007548479.2.
DR AlphaFoldDB; A0A087Y519; -.
DR STRING; 48698.ENSPFOP00000013122; -.
DR Ensembl; ENSPFOT00000013140.1; ENSPFOP00000013122.1; ENSPFOG00000013097.1.
DR GeneID; 103135646; -.
DR KEGG; pfor:103135646; -.
DR CTD; 1896; -.
DR eggNOG; ENOG502QUAV; Eukaryota.
DR GeneTree; ENSGT00730000111220; -.
DR OMA; REITHQK; -.
DR OrthoDB; 5361136at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151:SF13; ECTODYSPLASIN-A; 1.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR Pfam; PF01391; Collagen; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 224..359
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 78..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..182
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..208
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 369 AA; 40152 MW; 0DE6F821151B4A78 CRC64;
MACDDASPAE DFPDTVMPRG APCMCGKKCR GRSGSAVFLG LFLLSLTLHA VTLVCYLDLR
SEVKREITHQ KRDSVVTHAG VDLDDPVGVL PPGHPRVDTG SRHSEEDREE RFLYRGDDDF
HGTKDSRGRT RRAKRSPARE TETESNGKER RKERKKAKKR PGPPGLPGPP GPQGPPGIPG
IPGIPGSNVV GPVGPPGPPG PQGPPGPQGP AGVSDKSKKF QPAVVHLQGQ ETTIQVREDL
SQGVLRNWKM VSINKDVFRM NPRTGELVVL LDGVYFIYSQ VEVYYLNFTD IASYDVMVDS
SPFLRCTCSI ETGQRKFNTC YTAGVSLLRS GQKISIRIAH EYTLINMTNH TTFLGSVRLG
EAPSAGQNG
//
