UniProt: A0A087Y5P4

Database: UniProt
Entry: A0A087Y5P4_POEFO

LinkDB:  A0A087Y5P4_POEFO 
Original site:  A0A087Y5P4_POEFO

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Ontology (4)   
   GO (4)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (19)   
   InterPro (10)   
   Pfam (4)   
   PROSITE (3)   
   SMART (2)   
All databases (31)   

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ID   A0A087Y5P4_POEFO        Unreviewed;      1179 AA.
AC   A0A087Y5P4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Integrin subunit alpha 1 {ECO:0000313|Ensembl:ENSPFOP00000013347.2};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000013347.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000013347.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR   EMBL; AYCK01017749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01017750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007576747.1; XM_007576685.2.
DR   AlphaFoldDB; A0A087Y5P4; -.
DR   STRING; 48698.ENSPFOP00000013347; -.
DR   Ensembl; ENSPFOT00000013365.2; ENSPFOP00000013347.2; ENSPFOG00000013129.2.
DR   GeneID; 103155135; -.
DR   KEGG; pfor:103155135; -.
DR   CTD; 3672; -.
DR   eggNOG; KOG3637; Eukaryota.
DR   GeneTree; ENSGT00940000157646; -.
DR   OMA; THTFLAI; -.
DR   OrthoDB; 3816176at2759; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR   Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR   Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR   InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR   PANTHER; PTHR23220:SF22; INTEGRIN ALPHA-1; 1.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF08441; Integrin_A_Ig_1; 1.
DR   Pfam; PF20805; Integrin_A_Ig_2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR   SUPFAM; SSF69179; Integrin domains; 3.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51470; FG_GAP; 5.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003762};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003762};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003762}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   CHAIN           25..1179
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT                   /id="PRO_5001422815"
FT   TRANSMEM        1135..1160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   REPEAT          29..87
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   DOMAIN          168..354
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REPEAT          365..416
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          476..538
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          554..613
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          617..677
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ   SEQUENCE   1179 AA;  131284 MW;  B1F6402DE30E7640 CRC64;
     MLRLSQFSTL TAAAVVVLLT CVLSFNVDQK NGLSFSGPLD DMFGYTVQQF ENSEGKWVLI
     GSPHSGQPAK RTGDVYKCPV GRGDNTCIKL ELPTNTTVPN LHEIKENMTM GTTLVTNPTG
     GFMACGPQYG YMCGQQQYIS GVCTNVSPSF QILNSIAPGV QNCTSNMDIV FVLDGSNSIY
     PWKNIVDFLI RFLERVQVGP KQAQVGIVSY GEDVKHHVNL SQFNNNKELL TFVKKIPQHL
     GTKTHTFLAI DTARKEAFTQ ERGARSDAKK VMVILTDGES HDHYLQKEVI GECDQDHIER
     FGIAVLGYYK RENKSEGEVK KFIDEIKSIS SKPTQDHFFN VSDEVFLVNL ADTLGRKIFA
     LEATSGNLTS SFDMEMSQAG FSAHAFKDGL LLGAVGAYDW NGTVVMQTAE STINPEKDEF
     YDPKDRKTRR GLAEYLGYDV QSASTPEGVL YITGAPRYNH TGRVVIYRLT KDSRVETVQI
     LRGEQIGSYF GSVLQTVDVN NDSFTDLLLV GAPMYMGPER DEQGKVYVYK LNERGKFVHK
     FDLNPMNQSC CSVNSDGCTM KNEPCGARFG TAIAAVSDLN LDGLNDVVIG APFENDHRGA
     VYIYHGHQSN RYLKLVQHIP AGGDGEKVKF FGQSIHGIMD LNGDGIVDVT IGGLGGASLF
     WSRDVAELTS NMTLEPAKIN LQHSQFQCEH KGHKSVCVNT TVCFQYRVKS EKRDASFTEM
     RYNITLDLPR AKARASFIDQ DLDKSDRRVT KTFSISNGQT ICKKERFIMS ARLDFKDPIN
     VTLEFGLTDE DKGPVLDASL PTSITKTIPL VDCGDQLKCI TDLSLTAEAS EKSMLIHVNS
     KDKLDVKIDI SNKRDNAYNT KVILSFTPNI NYVKVEPEKE CTPDNTKVEC AVGYPFLGSK
     AKESFKVRFE TDSSHIHENI YINVTTVSDS EENPNTLHDN SKEIFIPVKY EAGVIFSVSH
     SQNYITIEDG EQSSVKDSDF GRMIEEVNIS YTVEKAGNTL TPALDLNVIY PYRSPLFNVL
     LFPTRIVYST EVKCKEPPAP KHNKPKKETL TPFLLECGQS LCDSFTCSIP ETNKSQVNVT
     FKAWKPTFTV GEFSSLKMMV NASLTFKQNH LFELGSNAKT RNVTILISKG TIEGIPLWII
     ILLSTLAGLL ILALIILIFW KLGFFKRKTM DYSKEEMSD
//

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