ID A0A087Y8I3_POEFO Unreviewed; 989 AA.
AC A0A087Y8I3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Sorting nexin 14 {ECO:0000313|Ensembl:ENSPFOP00000014336.2};
GN Name=SNX14 {ECO:0000313|Ensembl:ENSPFOP00000014336.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000014336.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000014336.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AYCK01015834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007574218.1; XM_007574156.2.
DR AlphaFoldDB; A0A087Y8I3; -.
DR STRING; 48698.ENSPFOP00000014336; -.
DR Ensembl; ENSPFOT00000014358.2; ENSPFOP00000014336.2; ENSPFOG00000014297.2.
DR GeneID; 103153295; -.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR OMA; MYVYVIS; -.
DR OrthoDB; 2877434at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR CDD; cd06877; PX_SNX14; 1.
DR CDD; cd08722; RGS_SNX14; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037436; SNX14_PX.
DR InterPro; IPR037892; SNX14_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 128..302
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 334..466
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 612..732
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 528..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 989 AA; 114302 MW; 3E451716EDBC365F CRC64;
MGSIRAFLQL TSRGMKLDRV RELGRQYPVF CFLLLVLLLT TLLLNRYIHI IMVFWSFLAG
VVTFYCSLGP ESLLPNIFVS IKPKTKSFQQ ELFPLGHSCA VCGKIKCKRH RPTLLLENYQ
PWLDLKIPSK VDASLSEILE LVLENVVYPW YREITDDDSF VDELRVTLRF LAAVLVRRIQ
KVDVASLITR KLLKVSMKHI EIISKARQKV KNAEYFQQAA LDEFGPDLHV ALRSRRDELL
YLRKLTEILF PYILPPKGTD CRSLTLLIRE VLAGSVFLPS MDYLADPDTV NHLILIFIDN
SPPEEATEPT SALVPFLQKY SDSRNRKPSV LKLELKEIRE QQDLLFRFMN FLKQEGAVHV
LQFCLAVEEF NDRILCPELS DSEKMMLHEE VKKIYETYCL DESIDKIRFD PFIVEEIRNI
AEGPYAEVVK LQTMRCLFEA YEHVLSLLEN VFTPMFCHSD EYFRQLLRGA ESPARNSKMS
RNSVSLDDIR SWDWSPESPS SLFTASGSSS PASFSSLHAQ STFTNFPYGS QTHRHSSPKN
TSKRGESFGI SRIGSKIKGV FKSTTMEGAM LPSYGLVEGE DDMVEEAMMV LEDDSPMEAT
STPSTPRNLS AWNITIPYID FYDDDVKRER IPVFCIDVER NDRKAVGHET EHWSVYRRYL
EFYVLESKLT EFHGSFPDAQ LPSKRIIGPK NYEFLTSKRE EFEEYLQRLL QHPELSNSQL
LADFLSPHSM ESQFLDKMLP DVNLGKIIKA VPSKLIKEKG QHLEPFIQSF FNSCESPKPK
PSRPELTILS PTSENDKKLF NDLFKNNANR SEVTEKRHNQ NYFMEMITVE GVYDYLVYVG
RVVFHIPDWF HHLLMGGRIL FKNSLEAYTD YYLQHKLNQV VQEHRLVSLI TLLRDAVFCE
SSPPRSAQDK QSRAKRTFEE MMSYIPDFLG KCIGEEAKYE GVRLLFDGLQ QPVLNKQLTY
VLLDIVIQEL FPELNKQVQK EPSAVAPWM
//
