ID   A0A087YBH4_POEFO        Unreviewed;       275 AA.
AC   A0A087YBH4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000015377.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000015377.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates feedback control of cholesterol synthesis.
CC       {ECO:0000256|RuleBase:RU241113}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU241113}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC       ECO:0000256|RuleBase:RU241113}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the INSIG family.
CC       {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AYCK01006233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007555682.1; XM_007555620.2.
DR   AlphaFoldDB; A0A087YBH4; -.
DR   STRING; 48698.ENSPFOP00000015377; -.
DR   Ensembl; ENSPFOT00000015399.2; ENSPFOP00000015377.2; ENSPFOG00000015325.2.
DR   GeneID; 103140452; -.
DR   KEGG; pfor:103140452; -.
DR   CTD; 3638; -.
DR   eggNOG; KOG4363; Eukaryota.
DR   GeneTree; ENSGT00580000081600; -.
DR   OMA; FWSCSCT; -.
DR   OrthoDB; 2943928at2759; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR025929; INSIG_fam.
DR   PANTHER; PTHR15301; INSULIN-INDUCED GENE 1; 1.
DR   PANTHER; PTHR15301:SF11; INSULIN-INDUCED GENE 1 PROTEIN; 1.
DR   Pfam; PF07281; INSIG; 1.
PE   3: Inferred from homology;
KW   Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548,
KW   ECO:0000256|RuleBase:RU241113};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU241113};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU241113};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Steroid metabolism {ECO:0000256|RuleBase:RU241113};
KW   Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU241113};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU241113}.
FT   TRANSMEM        87..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        181..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        209..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        240..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
SQ   SEQUENCE   275 AA;  30466 MW;  B9DBC0C45FCD751D CRC64;
     MSRRGGFYLN QTQKPSREQE QKCQMPRLED HCWSCSCSPK AETKHSSGAN WFASKAEEMM
     SIITAMLGSA YGSLHDVRTA NLIRRGLVLF TVGAFLALVL NLLQIQRNVT LFPEEVMTTL
     LSSAWWIPPC CGTGAAVIGL LYPCLDSHLG EPHKFKREWA SVMRCIAVFV GINHASVKLD
     FANNVQLSLT LAALSLGLWW TFDRSRSGFG LGITTAFLAT VITQLLVYNG VYQYTSPDFL
     YVRSWLPCIF FSGGVTVGNI GRQLAMGGVE KPHMD
//