ID A0A087YM97_POEFO Unreviewed; 867 AA.
AC A0A087YM97;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=T-cell activation Rho GTPase-activating protein {ECO:0000313|Ensembl:ENSPFOP00000019150.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000019150.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000019150.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01000258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01000259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007545865.1; XM_007545803.2.
DR AlphaFoldDB; A0A087YM97; -.
DR STRING; 48698.ENSPFOP00000019150; -.
DR Ensembl; ENSPFOT00000019172.2; ENSPFOP00000019150.2; ENSPFOG00000019037.2.
DR GeneID; 103133856; -.
DR KEGG; pfor:103133856; -.
DR CTD; 447809; -.
DR eggNOG; KOG4724; Eukaryota.
DR GeneTree; ENSGT00940000157993; -.
DR OMA; NTKPEFN; -.
DR OrthoDB; 2964977at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR PANTHER; PTHR23179:SF26; T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 287..473
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 489..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 96745 MW; E0DD46C141CB01DC CRC64;
MDLTDYGVAA MRRGSYDDAA ASMHPHFRHL AQRRRSAPSL VFGKALGMPW SPIREEAPCW
VSVEQSPFVL GLTSENGELL LDECVQVTEG TKTKERHLFL FTDVLIFAKL KSTASYRLKQ
RVNLEDVWLC DFEEEEKEEE DDSGTAGDVD PRLTLVLAWA LTFCIVCFRS PEVKERWSDT
LHRKIRDAIT RTGCASSSPP DVLMKVLSGS IATKTLTGGG MEQIIVLTPE GDAKSCALSK
QLNNQEERLT QSSETKWNLV RNKMKLRRTS SKACHANKGT KNQLFGQPLS NICPDDYSLP
KPITDLLVLL RKMGPSTEGV FRKPCNTRLM KDLREQLDNG TDVDLESQQV HLLVGLLKCF
LKELPHSLLR SDLYNRWTAA LDHEDTEQRT LEIRRVFDDL PGPNKLLLQY LVCLFHCILE
SSDTNKMDAS NLAVCIGPTL LQLDGTPLDV QREKMQKATE LTQFLIENCG ILGENIPCLL
DTDEDSLSSV HHDSAYDSTD PDGDGEAGEK RSSTDGGRGS SSSYSSLSPS ITTPSWQSDA
AFDNKAPFNR RCSEPILLLP ESLENLCSHA RSHDDCSMQR DNFDGQPLKK QISDDSFLLK
SRGGASSVLS FPKLSCSSNM DPLPYMGKDC SCSSLESTAS NQSESSVFTS SPMGSPRSSK
KDNSQALVTT NGKLDVPKLI SEEKRRSQSM RVASKVLMRT RSLGAFSRSS LKKDAPKENP
FPETLQEDSQ SEADPSADVV LKPRPLSAIE VFKQVDSRLP SRPPSYEQAV QNIAPPPHYG
SMTVQDAITQ IRRSRPSSMN YDLPVREYSY NQDCFSQTAQ DTIVERRQPF RQRAMSESVS
KGQHEMVSRR CSQPVFEEFS YAKESYV
//
