ID A0A087YNP9_POEFO Unreviewed; 1219 AA.
AC A0A087YNP9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000019652.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000019652.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AYCK01004490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01004491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087YNP9; -.
DR STRING; 48698.ENSPFOP00000019652; -.
DR Ensembl; ENSPFOT00000019675.2; ENSPFOP00000019652.2; ENSPFOG00000019516.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000166212; -.
DR OMA; MAIGPCI; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF448; PROTEIN JAGGED-1; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 9.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 14.
DR SMART; SM00214; VWC; 1.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 11.
DR PROSITE; PS50026; EGF_3; 15.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1219
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001834829"
FT TRANSMEM 1063..1087
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 179..223
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 224..257
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 290..328
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 331..367
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 369..405
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 407..443
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 445..480
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 482..518
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 520..556
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 586..622
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 624..660
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 662..698
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 700..736
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 739..775
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 777..813
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 815..851
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1147..1206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 181..190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 194..206
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 214..223
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 247..256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 318..327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 357..366
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 395..404
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 433..442
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 449..459
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 470..479
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 508..517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 546..555
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 612..621
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 650..659
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 688..697
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 726..735
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 765..774
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 803..812
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 841..850
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1219 AA; 133535 MW; 2147DBD9DA3CA59D CRC64;
MILRRSSAVA AFFLLCFLVE VSQGSGQFEL QILSMHNANG ELPNGMCCDG ARSAADRKCA
RSECDTFFKV CLKEYQSRVS AAGPCSFGMG STPVLGGNTF SFRSPVRNDK SRIVLPFSFA
WPRSYTLIVE AWDFNNETGG SDGKLIEKAS HSGMINPSPQ WQKLIHNGPV AQFEYEIRVS
CDEHYYGFGC NKFCRPRDEF FGHYTCDYNG NKTCLEGWSG PECNTAICRQ GCSTEHGSCK
EPGECKCLYG WQGLYCDKCI PHPGCVHGTC VEPWQCLCDL NWGGHLCDKD LNYCGTHQPC
LNGGTCINTG PDKYQCTCAE GYSGANCERV AEHACLSNPC SNGGSCSETA QGYECQCAPG
WSGPSCTTNV DDCSPSPCNH GGTCQDLVNG YKCHCPPQWM GKTCLIDANE CDSKPCVNAN
SCRNLIGSYF CECLPGWTGQ NCDTNINDCK DQCLNGGTCK DLVNGYRCTC APGFAGDHCE
RDVDECASSP CLNGGRCQDE VNGFQCLCLT GFSGNLCQLD IDYCSPNPCQ NGAPCYNRAT
DYFCACPEDY EGKNCSHLKD HCRTTTCKVI DSCTVAVASN STPGGERYIS SNVCGPHGRC
RSQAGGQFSC ECQEGFRGTY CHENINDCES NPCRNGGTCI DKVSVYQCIC ADGWEGDHCE
INIDDCSTNP CHNGGTCRDL VSDFFCECKN GWKGKTCHSR ESQCDEATCN NGGTCHDEGD
TFQCKCSPGW EGTTCNIAKN SSCLPNPCEN GGTCVVKGDS FTCVCKEGWE GPTCTQNTND
CSPHPCYNSG TCVDGDNWYR CECAPGFAGP DCRININECQ SSPCALGSTC VDEINGYRCL
CPPDRTGLHC QNVETRKHCS SNGHVAPDGA SWEEDCNICH CSNGKVLCTK MWCGPKSCKL
GAKGRGGCPP DQSCMPLREA HCFVKPCLEL GECWGSGLAQ PRIKCHPSSS YQDNSCANIT
FVLKKEIMPA GLTVEGVCKQ LRNLNIVRNF SLEHSVTITC DPSFSASNEI HVCLSTEDHR
LDRNPIKEIT DRIIDLVNKA NGNNTILSAI VKVQVPRPSK TDYLVPLLSS IFIVIWFLLL
VSVLLWCMRR RRKQSNHNGT LPSGSEDNTT NNVREHLNQI KNPIEKHVGL TVAIKDYENK
NSIIAKIRTN HPEGDEDDKE RHLQKGRFAK QPAYTLVERD EKAPISNPNP TSKHPNWTNK
QDNRDLETAN SINRMDYIV
//
