ID A0A088ESN4_9SPHI Unreviewed; 650 AA.
AC A0A088ESN4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=KO02_01170 {ECO:0000313|EMBL:AIM35426.1};
OS Sphingobacterium sp. ML3W.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Sphingobacterium.
OX NCBI_TaxID=1538644 {ECO:0000313|EMBL:AIM35426.1, ECO:0000313|Proteomes:UP000028992};
RN [1] {ECO:0000313|EMBL:AIM35426.1, ECO:0000313|Proteomes:UP000028992}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ML3W {ECO:0000313|EMBL:AIM35426.1};
RX PubMed=25614576;
RA Smith S.A., Krasucki S.P., McDowell J.V., Balke V.L.;
RT "Complete Genome Sequence of Sphingobacterium sp. Strain ML3W, Isolated
RT from Wings of Myotis lucifugus Infected with White Nose Syndrome.";
RL Genome Announc. 3:0-0(2015).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; CP009278; AIM35426.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A088ESN4; -.
DR STRING; 1538644.KO02_01170; -.
DR KEGG; sht:KO02_01170; -.
DR eggNOG; COG3525; Bacteria.
DR HOGENOM; CLU_013588_0_0_10; -.
DR OrthoDB; 1006965at2; -.
DR Proteomes; UP000028992; Chromosome.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000028992};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..650
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001836649"
FT DOMAIN 26..146
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 149..249
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 289
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 650 AA; 74660 MW; AABA425C2E701BC8 CRC64;
MKFNRILLSL LVLSISCLSP TYAQENLIPL PIKMELRDGA LNLSNGIILK KTDSSLTGEY
LLASAIIAEW KVAESAVNNK QLPTLDLQLI DDESDQKQRE DYIIKIDNGG IRIIAHSPTG
IFYGLQTLRQ FSVQNKSLAH CEINDQPAFP WRSFLVDVGR NYQPLHLLKE QVDIMAQYKM
NVLHFHFTED VAWRLASKKY PNLTAASNIT RGGGEHYSEQ EFKELIAYCK ARHILLLPEI
DMPGHSQAFK RYFGVDMQSD SGIVYIKELL KEFSQTYQDL PYLHIGGDEV KITNKNFMPE
ITEYVEELGY KTIGWEPGSN LMPQTIRQLW MGGPKRIPEQ GDLIYIDSKH LYINHMDPLE
TVTTLFHRKI GEQDKEHKNL IGATLCAWPD RAVSKPLDMF YQNAVYPALV TFAERVWRGG
GLAGWTCNIV DENTIAYQEF KNFENRLLNH KNMYFSNKPF PYVKQTGLKW ELIGPFQNEG
NLTRSFPIEQ QPYADGIEVT KTVEGGTIIL RHWWADIIPG AIEGPLPNTT WYARTKIWSD
KNENKSFWIG FNNLSRSYAS NTPKKGTWDN LESKVWVNHQ PIQPPLWQQA GIKGDLEVPL
IDEGYTFRKP TQISLKKGWN EVLIKLPVSD FKGEDWQNPV KWMFTLIPSN
//
