ID A0A088EZX4_9SPHI Unreviewed; 519 AA.
AC A0A088EZX4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=KO02_10020 {ECO:0000313|EMBL:AIM36992.1};
OS Sphingobacterium sp. ML3W.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Sphingobacterium.
OX NCBI_TaxID=1538644 {ECO:0000313|EMBL:AIM36992.1, ECO:0000313|Proteomes:UP000028992};
RN [1] {ECO:0000313|EMBL:AIM36992.1, ECO:0000313|Proteomes:UP000028992}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ML3W {ECO:0000313|EMBL:AIM36992.1};
RX PubMed=25614576;
RA Smith S.A., Krasucki S.P., McDowell J.V., Balke V.L.;
RT "Complete Genome Sequence of Sphingobacterium sp. Strain ML3W, Isolated
RT from Wings of Myotis lucifugus Infected with White Nose Syndrome.";
RL Genome Announc. 3:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP009278; AIM36992.1; -; Genomic_DNA.
DR RefSeq; WP_038697873.1; NZ_CP009278.1.
DR AlphaFoldDB; A0A088EZX4; -.
DR STRING; 1538644.KO02_10020; -.
DR REBASE; 92828; M.SspML3WORF10020P.
DR KEGG; sht:KO02_10020; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_013049_4_1_10; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000028992; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000313|EMBL:AIM36992.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028992};
KW Transferase {ECO:0000313|EMBL:AIM36992.1}.
FT DOMAIN 12..133
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 149..476
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 480..507
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 519 AA; 59982 MW; 9A75EC7DE41AE8D2 CRC64;
MAKKVQTKST EEILWDSANK LRGSVEPSEY KHIVLSLIFL KFANDKFLKR REQLIAENKE
AFLEIPEFYQ AENVFYLPEE SRWTYIIENA KQEDITLKVD SALKTIERTN KSLEGALPDN
YFSRLGLDQS KFSALLDTIN NIDTLKDESQ DIVGRVYEYF LSKFAIAEGK GKGEFYTPKS
IVNLIAEMIE PYKGKIYDPS CGSGGMFVQS LKFIEKHQGN KKDISIYGQE LTNTTFKLAK
MNLAIRGISA NLGNKAADTF GDDQHKDLKA DYIMANPPFN LKDWRAENEL TDDPRWAGYE
VPPKSNANYA WILTMISKLS QNGVAGFILA NGALSGGGEE YKIRKQIIEN DLVEAIVILP
RAMFYSTDIS VTLWILNRNK NERTFEVNDG VKKYRNRKCE VLFMDLRQKG EPFEKKFIQF
DDEEITTIAA HYHNWQQNNW EETYQNVPEY SYSASLDEIR KKDYSLVPSK YIEFVNRDEN
LDYDEQMQSL QTDLKDLFKQ ESQLKKEVSD VFKTLGYEL
//
