ID   A0A090L7H9_STRRB        Unreviewed;      1018 AA.
AC   A0A090L7H9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=HECT domain-containing protein {ECO:0000313|EMBL:CEF65716.1, ECO:0000313|WBParaSite:SRAE_2000039200.1};
GN   ORFNames=SRAE_2000039200 {ECO:0000313|EMBL:CEF65716.1,
GN   ECO:0000313|WBParaSite:SRAE_2000039200.1,
GN   ECO:0000313|WormBase:SRAE_2000039200};
OS   Strongyloides ratti (Parasitic roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF65716.1};
RN   [1] {ECO:0000313|EMBL:CEF65716.1, ECO:0000313|Proteomes:UP000035682}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC   ECO:0000313|WBParaSite:SRAE_2000039200.1}, and ED321 Heterogonic
RC   {ECO:0000313|EMBL:CEF65716.1};
RA   Martin A.A.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SRAE_2000039200.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (DEC-2020) to UniProtKB.
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DR   EMBL; LN609529; CEF65716.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A090L7H9; -.
DR   STRING; 34506.A0A090L7H9; -.
DR   EnsemblMetazoa; SRAE_2000039200.1; SRAE_2000039200.1; WBGene00260586.
DR   WBParaSite; SRAE_2000039200.1; SRAE_2000039200.1; WBGene00260586.
DR   WormBase; SRAE_2000039200; SRP04938; WBGene00260586; -.
DR   eggNOG; KOG4427; Eukaryota.
DR   OMA; CILINDY; -.
DR   OrthoDB; 1386at2759; -.
DR   Proteomes; UP000035682; Chromosome X.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700:SF3; UBIQUITIN-PROTEIN LIGASE E3B; 1.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          655..1018
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        986
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   1018 AA;  118746 MW;  313861A242E6503D CRC64;
     MDEIKKELQE FIGPTTTTNE DSTRNNIVSN LKNIQMLNYA TYFLYLQQKN ELKMYSDNFV
     LLIRTIIKSL EYSDSKVSFA ALFLSKIYLK KANNLVKKIF EYIPKFLDSL DVSTYGYSRN
     YATMVHFLIS FTSTSSWKVI QTNQTIQIAL SSMFPQLLAI LFSHESFENF YSTFKKAFSE
     KKIILGNECV DGIFLLFLKS LKSNDLNCKK TIYIFIELMK IPSIIQCLSN ISFKKMADDK
     IYTQLLLFYY NNSEFFTNSL HQSNYLSYFA NFIDLSNHFQ NEMYENLFEW LHHVHLCLKL
     FRELVPNTKN ITKNRTTYWH PLFGNIIFNL ESTNTDAFKL MRKQLSLLWS KQFLKLLFYN
     LLEKRESNNG KKNFNGILKK SDIESNISGL SLGDVRNSIQ GLLKTFVKNC NTTSIPSPGI
     STLICDLYYN ILETFQNIQL DILAAITSDD LILPALWSHI NRDNRSLNFY FKILPQYKKF
     ESPHFSVLIL FSKATISILN LLDEKEMYEI QKPFSLDELC EIGRFTNHFC FKVIWNKIIK
     IEQPKDHPVY EAMYKLLNIL YNRDWRRSFT NSYKKFWIAP DTKGTSIINM YENDDKEAKF
     IMTYLPHIIP LMDRVEYFRK IVGREKDAYA SPAKSITIER THIIEDGYRQ LNGMNPKDLK
     NTIRVKFINA QGLDEAGIDR DGVFKEFLEL TLRQVFDPQL NLFHTTENNY IMPSPTSYFH
     EDHLQLFLFV GKMLAKSVYE GIVTDLKIAP VLLAIMTGKK LSAFDELSKL DPNLYKSLTY
     IKYYNDSDDI GDLDLTFSVD EQELGVIKTI DLIPGGRHIA VTNENKIRYI HTMAQYRVYV
     QTKEQNAAFV KGFTSVLDQT WLNFFSPHEI QFLISGNNDD INIADLKMHV HYYGGFHSQH
     KVIKWLWEIL EKDLKPEERR LFLKFVTSCS QAPLQGFKHL YPQFSIRCVE YGDDDDPGDT
     IGSVVRGFFA IKKKSNNDRL PTSSTCFNLL KLPNYSKKSI LLEKLRYAIH AGTGFELS
//