ID A0A090LC00_STRRB Unreviewed; 220 AA.
AC A0A090LC00;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 {ECO:0000256|ARBA:ARBA00040793};
DE EC=3.1.7.2 {ECO:0000256|ARBA:ARBA00024387};
DE AltName: Full=Metazoan SpoT homolog 1 {ECO:0000256|ARBA:ARBA00041464};
DE AltName: Full=Penta-phosphate guanosine-3'-pyrophosphohydrolase {ECO:0000256|ARBA:ARBA00041770};
GN ORFNames=SRAE_2000194100 {ECO:0000313|EMBL:CEF67277.1,
GN ECO:0000313|WBParaSite:SRAE_2000194100.1,
GN ECO:0000313|WormBase:SRAE_2000194100};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF67277.1};
RN [1] {ECO:0000313|EMBL:CEF67277.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_2000194100.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF67277.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_2000194100.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- FUNCTION: ppGpp hydrolyzing enzyme involved in starvation response.
CC {ECO:0000256|ARBA:ARBA00037781}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP +
CC H(+); Xref=Rhea:RHEA:14253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:58189, ChEBI:CHEBI:77828; EC=3.1.7.2;
CC Evidence={ECO:0000256|ARBA:ARBA00024273};
CC -!- SIMILARITY: Belongs to the MESH1 family.
CC {ECO:0000256|ARBA:ARBA00038354}.
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DR EMBL; LN609529; CEF67277.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090LC00; -.
DR STRING; 34506.A0A090LC00; -.
DR EnsemblMetazoa; SRAE_2000194100.1; SRAE_2000194100.1; WBGene00262148.
DR WBParaSite; SRAE_2000194100.1; SRAE_2000194100.1; WBGene00262148.
DR WormBase; SRAE_2000194100; SRP09189; WBGene00262148; -.
DR eggNOG; KOG1157; Eukaryota.
DR OMA; PPWRERK; -.
DR OrthoDB; 2783605at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR PANTHER; PTHR46246; GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1; 1.
DR PANTHER; PTHR46246:SF1; GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1; 1.
DR Pfam; PF13328; HD_4; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:CEF67277.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682}.
FT DOMAIN 76..171
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 220 AA; 25000 MW; 3935A585075407FC CRC64;
MDSKEKCNLY PELPVKKSDD NQGSPPPPYE SPESESSDDV VLPIPVEGMA LVIKAADFAA
RRHRFQKRKD HKGTPYINHP LGVAYILTNE ANIYDPVTLA AAILHDTVED TKTTIDEINS
LFGPEVAHIV DECTDDKSLP KDVRKKLQIE TAASHSFKAK LIHLADKLYN IRDLSRNVPQ
GWDTRRIKNY YKWCREVVNQ IRGTNETLEK ALDKIFDEKC
//
