ID A0A090LJ41_STRRB Unreviewed; 4137 AA.
AC A0A090LJ41;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Cubilin {ECO:0000313|EMBL:CEF69718.1, ECO:0000313|WBParaSite:SRAE_2000436500.1};
GN ORFNames=SRAE_2000436500 {ECO:0000313|EMBL:CEF69718.1,
GN ECO:0000313|WBParaSite:SRAE_2000436500.1,
GN ECO:0000313|WormBase:SRAE_2000436500};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF69718.1};
RN [1] {ECO:0000313|EMBL:CEF69718.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_2000436500.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF69718.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_2000436500.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; LN609529; CEF69718.1; -; Genomic_DNA.
DR STRING; 34506.A0A090LJ41; -.
DR EnsemblMetazoa; SRAE_2000436500.1; SRAE_2000436500.1; WBGene00264596.
DR WBParaSite; SRAE_2000436500.1; SRAE_2000436500.1; WBGene00264596.
DR WormBase; SRAE_2000436500; SRP00709; WBGene00264596; -.
DR eggNOG; KOG3579; Eukaryota.
DR eggNOG; KOG4292; Eukaryota.
DR OMA; CDWHIAV; -.
DR OrthoDB; 2917265at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 15.
DR CDD; cd00054; EGF_CA; 5.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 22.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF37; CUB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 15.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR SMART; SM00042; CUB; 21.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 22.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01180; CUB; 23.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..4137
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015030794"
FT DOMAIN 164..200
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 202..243
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 295..334
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 380..424
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 428..465
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 466..502
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 510..642
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 646..771
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 777..903
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 904..1032
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1036..1155
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1161..1272
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1276..1401
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1402..1530
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1532..1657
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1669..1794
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1943..2058
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2204..2330
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2331..2461
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2465..2586
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2588..2718
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2722..2867
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3013..3137
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3143..3269
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3270..3418
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3420..3544
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3551..3679
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3683..3816
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3817..3972
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 190..199
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 233..242
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 455..464
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 492..501
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1402..1429
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 4137 AA; 470669 MW; DEF4CF8BA583E4F1 CRC64;
MRKKYFNFSS ILIFLIFTVH GEFNDIFDDD ERMSRIVMVN GNMAFHAGIS KNISFHVSKD
SGIFFQSMDI TSLPNKSDID NLTEKWRQTL DAVYLIRRNV IGNQISGTSM KAKLLRLDSA
IKNLTITTGN MTILNNNKQR QMKRIARMLS IFQTNLHELL KVLKTDRCIG NPCLNGGQCF
NTYIGYHCLC PDTWTGTNCD RDVNECLLYE GTSRGCQNDG KCINKLNGFY CECKESYHGE
LCQSQKSSCN NDIELCGEHG HCVDLVQPKN GINYMCICPY GFKNHNDSNN PYCEDIDECQ
NNPCYPGATC INLPGSFKCT GCPKGTQGNG IICLDIDECL DERLNDCSKN PLVKCINTYG
SYKCDECPPS YEGDGYTCKK ISKCKNNLCP NDSICTEVPD ALDGYICTCP DGTSSDKGYN
GDCNSSNTNN PCNYKECKNG GTCYATGWFS FSCICPFGYS GNMCQYPTAC LEHNCNNRGN
CIINDKDGIC ECYPGYYGSE CQFEDTFLGC NIDISNQTGK LSLERLFFWD EKVGIDHCSW
NIKIPGSNNV TVLDIRTLLN NDTVSNHEDE RYDCDINESA IIIRDGETKN APIVGNFCKG
PKNSLVPVIN RKIILSGSRF KIEFTPLLNN ASSDFFINWF TIPKRCGGLL KNSFGEIDFK
QGINMTHCVW YIEVNLDHHI QIEIDRVSMI TQKRVNCTVN SLQIFDGNRI TSDQKVNEVC
SNENDKILVS TTGPYATIYW SNDNQKDIYN KDDCISEKEC NFGFKLSYKI TELPSGCGGE
ILPNENGEFE GFIQSPNYPN NYFSNLDCLW KLNSTGTPLS YLLDHVIKLN IIDFDIPVKK
EDYFCTNSYL KVMENSLSSS GIQYCNNFKP SHTYSYSGNT LLIKFHSDSI NKGKGFLLSY
KSSCEKHFYL QNGTIRSVNY PNSSPYPINC KYIIYSPPTR GIKIKIIDFD LIQPINICYG
TPEIIDGIQD YIKFSGPHSS NKLFNKKHIC KRFPLIPPNG EIITSGTRPL TINYVNSGSP
NNKGFHFEYE TFELGCGGIF EDINGTITSP NYPDGYLENL YCVYHISTEI NKLIRLTFQT
FDIEASSSDK DHCDSDVVGI YENYTTETEH GTLIGEFCGS ILPPSIVSSS NKLTIVLRTD
RSVKGIGFKA IYESIPSDEN CNKLFTSPSG VIEYDGSINN NWLQCDYSIR LPRNKRILIK
FNNFTIPCID SILFVRNGLG IDSPGFKGLH GMSEICSGHS VSSLRTHSNF FFMRLVTSNP
KKTKFSISYE QYNGGCGGKL SGLSGSISTP HFPEKDKHSY DCEWHIVGSL GNQIKFNIIS
MDDLSIPISN DKNYCHGYMS NSIDIYEGYT KGYEKLISYC YKEDQLSSII SEGNDMIIKY
KQNQHGTRDS IYGFLGEYTT HCKGVLLNDF TGHIQNPGYG YNVNEHISCN WRINVGKGNR
IRVKIIEFDI YESSKHININ KCNDNWLKIG DYQIKYMENR NDINYNSTFN DFCSDTNIIH
NFESVNNILD ISYNTYNMPN NKFWIYYETI GCGGIINENN TIIMISNITT PELFSNTNRL
PFECRWKIIA PFGYNIKINL EKILINRAED ELDSECLYGL SYYSGPNNNT GIPQRQYCSK
SYDKSYISHS NELFVLINAQ LGTYSFDKKD NIMFKALIEF TQSNIDSDCG GDIHLNTNQI
IPFHTINYPK PYIKGINCKW KFTSPSGYSV GYRIKTFNGG NMGTVKLPFI KKLNKYNLTE
CSNSNLRIFG FLFIKTYNYL LKEYHPFLTT CGYSDIDKPI YINTIHNNSI VEFRGASLDL
ALISNEKNNK PIGLLMEAFT VCGGELIATK ERKIYNFNNI YDDNCTIIII PPEKEGEIDI
IKVKLTSIWL GKTNTTINDK PTMFNFTCST DTISEPWSIS RSNYENRWYS FSCQGSIIIN
IYNITKESMN NMILQYGINS HFCGGELKGN GLEEADSKSK DFECTYTYSN ALGNNVEIQI
ENINIPWSEN CIDGYFEIRK YNESGDVLGR FCGNDDDNIN SRGIGKTFEG NILWMRYKVK
MNNLLQDDNE FYTSIKFNKN AKIGGYVEGN VIESSSYMEP NKIYTWNIIE QNIKGISLKI
ESLYIPNSDN SDIIECKSSK LCEGLTIMSG ICDDDQDWET CGHVLYNLNG YIGDDRELIL
KGNEFTIGLY AKTKVSFHLS WTYLYTTPDL LNHTKNEIDT DFNCGGMLNP SFTVQVLKNP
SITGSINYPP DTRCKWTIKR PLFRGIELKL VYVDLESTLN CRYDYLYVTK NSYTKTSEIP
FETDTDKRVC DILSMKKLTM TLTDDSELNI YFVSDRSRQG RGFLLEYRLL CDSKEFFEAD
NGNFVGTLLS PNYPDPYPSN ISCSWSISTD SFRRIEVIPN EIDLKTNDDG SCKNDILKIS
GKIPDNGTML GFLEYSKLLQ YETCKKSFTN ITFVHGKIQI NFKSGIEENT KKGFSLKISE
IVDPCSDMHL VIDEDNPTKI LTSPKWPNYS PNSLNCGWKI SAPIGHRIKF NIDPETFNME
ESSGGECVND YLQIFDGPSK KNKLIGRYCN NKGPETIFST SNYLFIHYKT DSMIPSHGFN
ATYSIADCGG TINLKPNIKF SLFSPRYPNY DQANHQCIWQ IRAPKNYQIL IDIKTLLISP
KSNCSNGYVS IRDSYIDNEN SYYILPPTCT KMYSKKPALK SKSHVIFVDY NITHVASKPN
ALLCSTGGCG FSFIFSLVKE NCGGIIDNFV GEIYSPGYPN SIIPGTKCEW KFKAGLDYRY
YIILEFLKNK ESFNLPVVGF SNNNEIEEEE CYNDIKIYNG FPPKDNYYNG PETMFCKGRT
NFVSTADLVT LKFEDQMKRS FGLASIMEKQ NMTSFSRHPF VIKYSKVPKE NYPYGCLHTI
KNDTSLVIGP LDLISNKDYP SGANSYCHLN IKRPEGSYTT MLKFSNFAVG PYSNRFCDLR
NNYINLKPTL TAIMKWEYNL CSHFNKTSTN FNIAVAIDEF DIFVYNSHRS KLGSTFLGQE
NTKFNLSVIF SKCGGLVKNM KGYITSPTYN TIDTNDNNKN FESCVWTLKA PENHIVKIKI
LNITLQSASN QVSDAFLNIY EGNTEDNAVL HRFSEKEHTL MKEFYNIKSN GQIIIIQWFI
GNYNTFKKGF KLQYEYVRED NECGYHIYGM NGTITSPGDD VYLNNLNCLW DISVPKGFLT
KLTFKRFDIE ESDDCNNDSL LISEYVEHSI EHRLSGSEIA QYKHYTFHKL CGNKKVPVPI
ISTTNGLRLN FTTNDKYAGK GFEIYWEAVC GGTIEAEFGE ITSPYYPLYY PSNIECNYVI
SNSKIRGSNG HSGGLILSVN VVDLSKEPSG DRDLNNPHLY DDNNKQNLKC KSDSLEIFDI
SSGKTLRKIC GYNYIEDKSK IYHYQDVGIK FISHPSKYEE DEKGMKHYKG FSISFIQNQC
NINVSLDDNI IEQNGNSIYE LFSPNYPKEY FPNMNCLINV TTLPGYIINA HIGDFHVEAS
EKCKFDYVEF FDGTIMNNKT SMGKLCGQLK NRKVIKSSNN SLLMKFKTDS SKHFKGYDIT
FTQSYGTDKN CGGKIDVTSN PKTIKAPIYK SKTNNNFFMD CVWELEAPRN KIIKITINEL
NLEKFKDKYL KGQCKDYLTI YDGIIGESST IVKEICDFKN YPDQSEIIMK TTNRIINIEL
LAYYKNSGQK EMDIEVVAID PECGGVLPTV DTMSIFAYKD KQLPTRDNQK HVRCKWYVYS
EERTPLEIMF TDFNVPAITL DCSEEYLEIR DVGSLVECQH PACAKNEDDK KVLKYCGTIK
PSLFISLSPV VQVTLSTFRT SQYQATIAFK YKTLGSCNRT ITISEEEHTL SGRFTSPNYP
NFYSHNTTCI TNFILDEKLK TSHKIFLVFD EVQLERGSSQ LLLTSTFYNP LHNNYKTKFL
HGLSGLNLPY RSMSQCRYDS LQIDDKIGNE TKIFCGNVVP PSHLSGGDIL SLNFTSDATT
NARGYSGTYF SVRTVKTDTY TIYKFESNYD SEGVITNVGF PFIQNKTTKS VWSIIPPRGS
KCSINLLFLK LPINPEDKNC KNEINQLFSI IHTDSEVLNE NSTLSTNAAM INIPCTFTET
QKFDLQEGKK FYIHYETKEV SDKVINNYEG FRLSWQCGKS NFVSKGFHGI RSKEFNY
//
