ID A0A090VKL5_9FLAO Unreviewed; 263 AA.
AC A0A090VKL5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=dTDP-4-dehydrorhamnose reductase {ECO:0000256|RuleBase:RU364082};
DE EC=1.1.1.133 {ECO:0000256|RuleBase:RU364082};
GN ORFNames=JCM19301_3770 {ECO:0000313|EMBL:GAL65310.1}, JCM19302_4100
GN {ECO:0000313|EMBL:GAL69371.1}, JCM19538_2097
GN {ECO:0000313|EMBL:GAL89108.1};
OS Jejuia pallidilutea.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Jejuia.
OX NCBI_TaxID=504487 {ECO:0000313|EMBL:GAL65310.1, ECO:0000313|Proteomes:UP000029641};
RN [1] {ECO:0000313|Proteomes:UP000029641, ECO:0000313|Proteomes:UP000029646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 19301 {ECO:0000313|EMBL:GAL65310.1,
RC ECO:0000313|Proteomes:UP000029641}, JCM 19302
RC {ECO:0000313|EMBL:GAL69371.1}, JCM 19538 {ECO:0000313|EMBL:GAL89108.1,
RC ECO:0000313|Proteomes:UP000030184}, and JCM19302
RC {ECO:0000313|Proteomes:UP000029646};
RA Takatani N., Nakanishi M., Meirelles P., Mino S., Suda W., Oshima K.,
RA Hattori M., Ohkuma M., Hosokawa M., Miyashita K., Thompson F.L., Niwa A.,
RA Sawabe T., Sawabe T.;
RT "Draft Genome Sequence of Marine Flavobacterium Jejuia pallidilutea Strain
RT 11shimoA1 and Pigmentation Mutants.";
RL Genome Announc. 2:e01236-14(2014).
CC -!- FUNCTION: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to
CC yield dTDP-L-rhamnose. {ECO:0000256|RuleBase:RU364082}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-
CC rhamnose + H(+) + NADPH; Xref=Rhea:RHEA:21796, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57510, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:62830; EC=1.1.1.133;
CC Evidence={ECO:0000256|RuleBase:RU364082};
CC -!- PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.
CC {ECO:0000256|RuleBase:RU364082}.
CC -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose reductase family.
CC {ECO:0000256|ARBA:ARBA00010944, ECO:0000256|RuleBase:RU364082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAL65310.1}.
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DR EMBL; BBNR01000001; GAL65310.1; -; Genomic_DNA.
DR EMBL; BBNS01000001; GAL69371.1; -; Genomic_DNA.
DR EMBL; BBNY01000005; GAL89108.1; -; Genomic_DNA.
DR RefSeq; WP_042240140.1; NZ_BBNY01000005.1.
DR AlphaFoldDB; A0A090VKL5; -.
DR STRING; 504487.JCM19538_2097; -.
DR eggNOG; COG1091; Bacteria.
DR OrthoDB; 9803892at2; -.
DR UniPathway; UPA00124; -.
DR Proteomes; UP000029641; Unassembled WGS sequence.
DR Proteomes; UP000029646; Unassembled WGS sequence.
DR Proteomes; UP000030184; Unassembled WGS sequence.
DR GO; GO:0008831; F:dTDP-4-dehydrorhamnose reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05254; dTDP_HR_like_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005913; dTDP_dehydrorham_reduct.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR029903; RmlD-like-bd.
DR NCBIfam; TIGR01214; rmlD; 1.
DR PANTHER; PTHR10491; DTDP-4-DEHYDRORHAMNOSE REDUCTASE; 1.
DR PANTHER; PTHR10491:SF4; METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA; 1.
DR Pfam; PF04321; RmlD_sub_bind; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|RuleBase:RU364082};
KW Oxidoreductase {ECO:0000256|RuleBase:RU364082,
KW ECO:0000313|EMBL:GAL65310.1}.
FT DOMAIN 4..262
FT /note="RmlD-like substrate binding"
FT /evidence="ECO:0000259|Pfam:PF04321"
SQ SEQUENCE 263 AA; 30418 MW; 8A72FE517C7CB28A CRC64;
MKKNILVTGA NGQLGQTIKE LYAVNKLGLN FVFVSKKELD ITNTKSIDTF FDKYKFEYCI
NCAAYTNVEQ AEKKPELAFM VNAEGIKNLA HKCKETNTLL IHISTDYVFD GEKKNPYTIN
DEPNPINEYG KSKLEGEKHI QNILGRYLII RTSWLYSKKY GNNFYKTILK KAKTEKELTI
TTAQIGCPTD TVNLSKFIIE LIQENKHKFG VLHFCDEKVM TWYDFAEQIL IDNNLYHKTK
LVKVKNYCTF AKRPKHVVLN TNT
//
