ID   A0A091CUU3_FUKDA        Unreviewed;       815 AA.
AC   A0A091CUU3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN   ORFNames=H920_17101 {ECO:0000313|EMBL:KFO21460.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO21460.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO21460.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO21460.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; KN124375; KFO21460.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091CUU3; -.
DR   STRING; 885580.ENSFDAP00000003554; -.
DR   eggNOG; KOG2165; Eukaryota.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR044554; APC2-like.
DR   InterPro; IPR014786; APC2_C.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF08672; ANAPC2; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   SMART; SM01013; APC2; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          495..693
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          443..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        459..476
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   815 AA;  93199 MW;  0E46BDA4E783C4BB CRC64;
     MSGDGSAGPG QELFVAWNTV STGLVPPALL GLASSRTSGA VPPKEEELRA AVEVLRGHGL
     HSVLEEWFVE VLQSDLQANI SPEFWNAISQ RENTADEPQG LLLLLDAFGL LESRLDPYLR
     SLDLLEKWTR LGLLMGTGAQ GLREKVHTML RGVLFFSTPR TFQEMVQRLY GRFLRVYMQS
     KRKGEGGTDP ELEGELDSRY ARRRYYRLLQ SPLCAGCGSD KQQCWCRQAL EQFHQLSQVL
     HRLSLLERVS AEAVTTTLHQ VTRERMEDRC RGEYERSFLR EFHKWIERVV GWLGKVFLQD
     GPARAASPEA GNTLRRWRCH VQRFFYRIYA SLRIEELFSI IRDFPDSRPA IEDLKYCLER
     TDQRQQLLTS LKAALETRLL HPGVNTCDII TLYISAIKAL RVLDPSMVIL EVACEPIRRY
     LRTREDTVRQ IVAGLTGDSD GTGDLAVELS KTDPASLETG QDSEDDSGEP EDWVPDPVDA
     DPGKSSSKRR SSDIISLLVS IYGSKDLFIN EYRSLLADRL LHQFSFSPER EIRNVELLKL
     RFGEAPMHFC EVMLKDMADS RRINANIREE DEKRPVEEQP PFGVYAVILS SEFWPPFKEE
     KLEVPEDIRV ALEVYCKKYE KLKAMRTLSW KHTLGLVTMD VELADRTLSV AVTPVQAVVL
     LYFQDQASWT LEELSKVVKM PVALLRRRMS VWLQQGVLRE EPPGTFSVIE EERPQDRDNM
     VLIDSDEESD SGMASQADQK EEELLLFWTY IHAMLTNLES LSLERIYSML RMFVMTGPAL
     AEIDLQELQG YLQKKVRDQQ LIYSAGVYRL PKSCS
//