ID A0A091D6N4_FUKDA Unreviewed; 931 AA.
AC A0A091D6N4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Protein unc-45 homolog B {ECO:0000256|ARBA:ARBA00020768};
GN ORFNames=H920_12654 {ECO:0000313|EMBL:KFO25940.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO25940.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO25940.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO25940.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, A band
CC {ECO:0000256|ARBA:ARBA00004161}. Cytoplasm, myofibril, sarcomere, Z
CC line {ECO:0000256|ARBA:ARBA00004216}. Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}.
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DR EMBL; KN123290; KFO25940.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091D6N4; -.
DR STRING; 885580.ENSFDAP00000000067; -.
DR eggNOG; KOG4151; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0031672; C:A band; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR024660; UCS_central_dom.
DR PANTHER; PTHR45994; FI21225P1; 1.
DR PANTHER; PTHR45994:SF2; PROTEIN UNC-45 HOMOLOG B; 1.
DR Pfam; PF11701; UNC45-central; 1.
DR SMART; SM00185; ARM; 4.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Myogenesis {ECO:0000256|ARBA:ARBA00022541};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 6..39
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 309..489
FT /note="UNC-45/Cro1/She4 central"
FT /evidence="ECO:0000259|Pfam:PF11701"
SQ SEQUENCE 931 AA; 103743 MW; 2619A40D01B53361 CRC64;
MAEVEAAQLK EEGNRHFQRQ DYKAAIKSYS QALKLTKDKA LLATLYRNRA ACGLKMESYA
QAASDASRAI DINSSDIKAL YRRCQALEHL GKLDQAFKDV QRCATLEPRN QNFQETLRRL
NTSIQEKLHV QFSTDSRVQT MFEILLDQNS ETEKREKAAN NLIVLGREEA GAERIFQNNG
VALLLQLLDT KRPELVLAAV RTLSGMCSGH QARTTAILHA VRIDRICSLM AVENEETSLA
VCNLLQAIMD SLSGEDKREH RGKEEALVLD TKKDLKQITN HLLDMLVSKK VSGQGRDQAL
NLLNKNVPRK DLAIHDNSRT IYVVDNGLRK ILKVVGQVPD LPSCLPLTDN TRMLASILIN
KLYDDLRCDP EREHFRKICE EYITSKFDPQ DMDKNVNAIQ TVSGILQGPF DLGNQLLGMK
GVMEMMVALC GSEREADQLV AVEALIHAST KLSRATFIIT NGVSLLKQIY KTTKNEKIKI
RTLVGLCKLG SAGGTDYGLR QFAEGSTEKL AKQCRKWLCN ATIDTRTRRW AVEGMAYLTL
DADVKDDFVQ DIPALQAMFE LAKASTSDKT ILYSVATTLV NCTNSYDVKE VIPELVQLAR
FSKQHVPEEH PKDKKDFVDM RVKRLLKAGI ISALACMVKA DSAILTDQTK ELLARVFLAL
CDNPRDRGTI VAQGGGKALI PLALEGTEVG KVKAAHALAK IAAVSNPDIA FPGERVYEVV
RPLVSLLDTQ RDGLQNYEAL LGLTNLSGRS DKLRQKIFKE RALPDIENYM FENHDQLRQA
ATECMCNMVV NKEVQERFLA DGNDRLKLVV LLCGEDDEKV QNAAAGALAM LTAAQKKLCL
KMTQVTPQWL EILQRLCLHD QLSVQHRGLV IAYNLLAADA ELAKKLVESE LLEILTVVGK
QEPDEKKAAV VQTARECLVK CMDYGFIKPV S
//
