ID A0A091D7E4_FUKDA Unreviewed; 1008 AA.
AC A0A091D7E4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Signal peptide, CUB and EGF-like domain-containing protein 2 {ECO:0000313|EMBL:KFO18726.1};
GN ORFNames=H920_19937 {ECO:0000313|EMBL:KFO18726.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO18726.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO18726.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO18726.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KN125342; KFO18726.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091D7E4; -.
DR STRING; 885580.ENSFDAP00000015167; -.
DR eggNOG; KOG1217; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 5.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 26..66
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 109..145
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 345..383
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 384..424
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 818..930
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 349..359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1008 AA; 111102 MW; ABE165B4EA7018D9 CRC64;
MVLGRAKAIA HTIGLHARCL LYSFAEIDEC AQRLDDCHAE ALCQNTPTSY KCSCKPGYQG
EGRQCEDIDE CENELNGGCV HDCLNIPGNY RCTCFDGFML AHDGHNCLDV DECLQNNGGC
QHTCVNVLGS YGCLCREGFL LSDNQHTCIH LSEEGLSCMN KDHGCSHICK EAPRGSVACE
CRPGFELAKN QRDCILTCNH GNGGCQHSCE DTAEGPECSC HPQYKLHPDG RSCLEQEDTA
LEVTESNATS VADGDKRVKR RLLMETCAVN NGGCDRTCKD TSTGVHCSCP VGFTLQLDGK
TCKDIDECQT RNGGCDHFCK NTVGSFDCSC KKGFKLLTDE KSCQDVDECS LDRTCDHSCL
NHPGTFACAC DAGYTLYGFT HCGDTNECSD NNGGCQQVCV NTVGSYECQC HPGYKLHWNK
KDCVEVKGFP PTRVLSYASL LCSKSGGGDR CLLRCHAGVR LSSGLQEAYS VTCGSSSLRS
KQHKSNDSAF GDVATIRTSV TFKLNEGKCS LKKSEPFPEG LRSALPEKHS SVKESFLYAN
LTCSSGKQVP GAPGRPSAHK EMFLTVEFER ETYQKEVTAS CDLSCISKRT EKRLRKALRT
LRKAAHREQF HLQLSGMDLD VAKKSPRASE QRAEACGVGQ GHVENQCVSC KAGTYYDGAQ
ERCILCPNGT FQNEEGQVAC DPCPRPENLG TLKTSDTWNV SLCGGLCQPG EYSADGFAPC
QLCALGTFQP EAGRTSCFPC GGGLPTRHLG ATSFQDCETR VQCSPGHFYN TTTHRCIRCP
AGTYQPEFGK NNCVSCPGNT TTDFDGSTNI TQCKSRRCGG ELGDFTGYIE SPNYPGNYPA
NTECTWTINP PPKRRILIVV PEIFLPIEDD CGDYLVMRKT SSSNSVTTYE TCQTYERPIA
FTSRSKKLWI QFKSNEGNSA RGFQVPYVTY DEDYQELIED IVRDGRLYAS ENHQEILKDK
KLIKALFDVL AHPQNYFKYT AQESREMFPR SFIRLLRSKV SRFLRPYK
//
