ID   A0A091DBN1_FUKDA        Unreviewed;       869 AA.
AC   A0A091DBN1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   SubName: Full=Rho guanine nucleotide exchange factor 26 {ECO:0000313|EMBL:KFO27908.1};
GN   ORFNames=H920_10667 {ECO:0000313|EMBL:KFO27908.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO27908.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO27908.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO27908.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN122840; KFO27908.1; -; Genomic_DNA.
DR   RefSeq; XP_010635194.1; XM_010636892.1.
DR   AlphaFoldDB; A0A091DBN1; -.
DR   STRING; 885580.ENSFDAP00000004945; -.
DR   Ensembl; ENSFDAT00000018445; ENSFDAP00000004945; ENSFDAG00000014061.
DR   GeneID; 104871064; -.
DR   CTD; 26084; -.
DR   eggNOG; KOG3523; Eukaryota.
DR   OMA; DRDGQKT; -.
DR   OrthoDB; 12272at2759; -.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd01221; PH_ephexin; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11938; SH3_ARHGEF16_26; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035797; ARHGEF16/ARHGEF26_SH3.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR047271; Ephexin-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR047270; PH_ephexin.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12845:SF4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          437..621
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          653..780
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          787..848
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          1..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..77
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..188
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   869 AA;  97152 MW;  60530AFF5A179BD0 CRC64;
     MDGESEVDFS SNRLTPLWRR RSTPEPQLVG RSKPRPQSYQ SPSGLLITDF PVEELGTLPA
     AQTPAQLPAS SDGGTVQRSP LFLCAHGGAV TNGRTVSPEY RAASPGPRRS KSPQVPKVAF
     GGSPKSRANG TVNPAPTLPL STPRTPAVAA PCSPEDPTGV TASRVPSPTV NGLASKNDSA
     GSCSQSAETA KDPERRPSGL CNVSQKTPLE QNLPLQRLPS RENELPENPS VVLSTNSPAA
     LKVGKQQIIP KSLASEIKLS KSTNQNVEPH KRLLKVRSMV EGFGAPLGPT GEEREVDNDL
     DSPGSLRRGL RSTSYRRAVV SGFDFDSPNS SKKKNRMSQP VLKVVMEDKE KFSSLGRIKK
     KMLKGQGTFD GEENAVLYQN YKEKALDIDS DEESELKEQK SEEKIVIHHK PLRSTWGQLS
     AVKRNGLSQT VSQEERKRQE AIFEVISSEH SYLLSLEILI RMFKNSKELS DTMTKTERHH
     LFSNITDVCE ASKKFFTELE ARHQNNIFIE DISDIVEKHT ASTFDPYVKY CTNEVYQQRT
     LQKLLATNPS FKEVLSRIES HGDCRNLPMI SFLILPMQRV TRLPLLMDTI CQKTPKDSPK
     YEVCKRALKE VSKLVRLCNE GARKMERTEM MYTINSQLEF KIKPFPLVSS SRWLVKRGEL
     TAYVEDTVLF SRRTSRQQVY FFLFNDVLII TKKKSEESYN VNDYSLRDQL LVESCDNEEL
     NSSPGKNSST MLSSRQSSAS HLFILTVLNN HANEKVEMLL GAETQSERAR WITALGHSSG
     KQPPDRTSLT QVEIVRSFTA KQPDELSLQV ADVVLIYQRV GDGWYEGQRL RDGEKGWFPM
     ECAKEITCQA TIDKNVERMG RLLGLETNV
//