ID A0A091DDF6_FUKDA Unreviewed; 1118 AA.
AC A0A091DDF6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN ORFNames=H920_08413 {ECO:0000313|EMBL:KFO30164.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO30164.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO30164.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO30164.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR EMBL; KN122476; KFO30164.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DDF6; -.
DR STRING; 885580.ENSFDAP00000011554; -.
DR eggNOG; KOG1172; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF20; ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 433..455
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 467..498
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 518..539
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 551..574
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 654..673
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 685..706
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 740..759
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 780..804
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 840..859
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 866..885
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 917..948
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 59..326
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 404..918
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 140..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1118 AA; 124824 MW; D4439AF0C70B8634 CRC64;
MDVISRTRSP AAEQLQDILG EEDEAPNPTL FTEMDTLQHD GDQMEWKESA RWLKFEEKVE
EGGERWSKPH VSTLSLHSLF ELRTCLQTGT VLLDLDRGSL PQIIDDVIEK QIEDGLLRPE
LRERVSYVLL RKHRHQTKKP IHRSLVDIGK SVSSTTSRSP ARNPAAGPSL RRSTEDLRIR
QSTNYGHLCH AQSRSMNDIS HTPNTDQRKN KFMKKIPKDS EASNVLVGEV DFLDQPFIAF
VRLIQSAMLG GVTEVPVPTR FLFILLGPSG RAKSYNEIGR AIATLMVDDL FSDVAYKARN
RKDLIAGIDE FLDEVIVLPP GEWDPNIRIE PPKKVPSADK RKSVFSLAEL GQMNGIVGGG
GETAGGGSNG GGAGGSGASG AGGGDDAEMP AAHEISEELI WTGRFFGGLC LDIKRKLPWF
LSDFYDGFHI QSISAILFIY LGCITNAITF GGLLGDATDN YQGVMESFLG TAMAGSLFCL
FSGQPLIILS STGPILIFEK LLFDFSKGNG LDYMEFRLWI GLHSAVQCLI LVATDASFII
KYITRFTEEG FSTLISFIFI YDAIKKMIGA FRYYPINTDF KPDSITTYKC ECVAPDPVNT
TVFNASAPLA PNTNNSLYIP INLTALDWSL LSKKECLSYG GRLLGNSCQF IPDLALMSFI
LFFGTYSMTL TLKKFKFSRY FPTKVRALVA DFSIIFSILL FCGIDACFGL ETPKLHVPSV
IKPTRPDRGW FVAPFGKNPW WVYLASILPA LLVTILIFMD QQITAVIVNR KENKLKKAAG
YHLDLFWVGV LMALCSFMGL PWYVAATVIS IAHIDSLKME TETSAPGEQP QFLGVREQRV
TGIIVFILTG ISVFLAPVLK YIPMPVLYGV FLYMGVASLN GIQFWERCKL FLMPAKHQPD
HAFLRHVPLR RIHLFTLVQI LCLAVLWILK STVAAIIFPV MILGLILVRR LLDFIFSQHD
LAWIDSILPE KEKKETDKKK KRKGAHEDSD EEPQFPPPSV IKIPMESVPS DPQNGIHCIA
RCSSPKMPPR AIHVFQVVEM IEKDLPVGVT HSDSSFTGLE LDRSITLHFK ISCPASPAFN
YSWNPVFMVP QVKIEMESDY DFTDVEEFAR EADRETTL
//
