ID A0A091DJJ0_FUKDA Unreviewed; 528 AA.
AC A0A091DJJ0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=PC4 and SFRS1-interacting protein {ECO:0000256|ARBA:ARBA00039324};
DE AltName: Full=Lens epithelium-derived growth factor {ECO:0000256|ARBA:ARBA00041831};
GN ORFNames=H920_08151 {ECO:0000313|EMBL:KFO30455.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO30455.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO30455.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO30455.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HDGF family.
CC {ECO:0000256|ARBA:ARBA00005309}.
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DR EMBL; KN122430; KFO30455.1; -; Genomic_DNA.
DR RefSeq; XP_010629254.1; XM_010630952.1.
DR AlphaFoldDB; A0A091DJJ0; -.
DR STRING; 885580.ENSFDAP00000022348; -.
DR Ensembl; ENSFDAT00000010202; ENSFDAP00000022348; ENSFDAG00000007041.
DR GeneID; 104866759; -.
DR CTD; 11168; -.
DR eggNOG; KOG1904; Eukaryota.
DR OMA; YTKNMNE; -.
DR OrthoDB; 4271850at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd20151; PWWP_PSIP; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR036218; HIVI-bd_sf.
DR InterPro; IPR021567; LEDGF_IBD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR PANTHER; PTHR12550; HEPATOMA-DERIVED GROWTH FACTOR-RELATED; 1.
DR PANTHER; PTHR12550:SF42; PC4 AND SFRS1-INTERACTING PROTEIN; 1.
DR Pfam; PF11467; LEDGF; 1.
DR Pfam; PF00855; PWWP; 1.
DR PRINTS; PR01503; TREACLE.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF140576; HIV integrase-binding domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 7..64
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 62..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 528 AA; 59797 MW; B7961F6FD2C21D92 CRC64;
MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET AFLGPKDIFP
YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQASTK QSNTSSDVEV EEKETSVSKE
DSDHEEKASS EDMTKAVDIT TPKAARRGRK RKAEKVETEE AGVVTTATAS VNLKVSPKRG
RPAATEAKIP KPRGRPKMVK PPCPSESDMV AEEDKSKKKG QEEKPKKQPK KDEEGQKEED
KPRKEPEKKE GKKEIESKRK NLAKTGVTST SDSEEEGDDQ EGEKKRKGGR NLQTAHRRNM
LKGQHEKEAT DRKRKQEEQM ETEQQNKDEG KKPEVKKVEK KRETSMDSRL QRIHAEIKNS
LKIDNLDVNR CIEALDELAS LQVTMQQAQK HTEMITTLKK IRRFKVSQVI MEKSTMLYNK
FKNMFLVGEG DSVITQVLNK SLAEQRQHEE ANKTKDQGKK GPNKKLEKEQ TGSKTLNGGS
EAQDSNQPQH NGDSNEESKD NHEAGSKKKP SGEERETEMS LKDSTVDN
//
