ID A0A091DRV8_FUKDA Unreviewed; 689 AA.
AC A0A091DRV8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Cell division control protein {ECO:0000256|PIRNR:PIRNR001767};
GN ORFNames=H920_03581 {ECO:0000313|EMBL:KFO34879.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO34879.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO34879.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO34879.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the initiation of DNA replication. Also
CC participates in checkpoint controls that ensure DNA replication is
CC completed before mitosis is initiated. {ECO:0000256|PIRNR:PIRNR001767}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR001767}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family.
CC {ECO:0000256|ARBA:ARBA00006184, ECO:0000256|PIRNR:PIRNR001767}.
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DR EMBL; KN121896; KFO34879.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DRV8; -.
DR STRING; 885580.ENSFDAP00000002700; -.
DR eggNOG; KOG2227; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR CDD; cd00009; AAA; 1.
DR CDD; cd08768; Cdc6_C; 1.
DR CDD; cd22077; WH2_WAS_WASL-2_3; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR016314; Cdc6/18.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR003124; WH2_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10763:SF26; CELL DIVISION CONTROL PROTEIN 6 HOMOLOG; 1.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR Pfam; PF13401; AAA_22; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR Pfam; PF02205; WH2; 1.
DR PIRSF; PIRSF001767; Cdc6; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SMART; SM00246; WH2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51082; WH2; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:KFO34879.1};
KW Cell division {ECO:0000313|EMBL:KFO34879.1};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|PIRNR:PIRNR001767};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 35..52
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 689 AA; 74904 MW; 4C9C68F3046AC4A9 CRC64;
MPIPPPPPPP PGPPPPTFNQ ANTEQPKLSR DEQRGRNALL QDICRGAKLK KVTNVSDRSA
PVLEKPKGSC GGGGYGSGAA ALQPKGGLFQ GGVPKLRPVG AKDGAGHVLL GVGEKPIRPF
PPVALGILAS IMPRTRSQAQ TTISFPKKKF SQTLDKTQNS KNAKLVPTNV QATPCPAEIL
PLSPRKRLGE DNLCNTPHLA PCSPPKQGRK ENGPPRSRTP KGRRLVFDDQ PAVKSPGKSK
QARAQRNRVG SSVQKGQESP GSREQRCLPE TEPTCLRLFK RAGTCYQQAK LVLNTAVPDR
LPAREAEMAV IGSFLRKHIC GRKAGSLYLS GAPGTGKTAC LSRTLQDLQK EVKGFRTIML
NCMSLRSAQA VFPAIAQELG QEEAARPAGK DIMRRLEKQM TSEKGPMIVL VLDELDQLDS
KGQDVLYTLF EWPWLSNSRL VLIGIANTLD LTDRILPRLE AREHCKPQLL NFPPYTRSQI
AAILQDRLHQ VSADHILDGA ALQFCARKIS AVSGDVRKAL DVCRRAIEIV ESDVKSQTIL
KPLSECKPAS ESWVPTRVGL AHIARVISEV DGSRVTLGSV GAQDSFPLQQ KVLVCSLLLL
TRQLKVREVT LGKLYEAYSS VCRKQQVAAV DQSECLSLSG LLESRGIVGL KKNKETRFTK
VSLKIEEKEI EHALKDKALI GNILATGLP
//
