ID A0A091DRW7_FUKDA Unreviewed; 536 AA.
AC A0A091DRW7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Growth factor receptor-bound protein 7 {ECO:0000313|EMBL:KFO34889.1};
GN ORFNames=H920_03591 {ECO:0000313|EMBL:KFO34889.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO34889.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO34889.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO34889.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GRB7/10/14 family.
CC {ECO:0000256|ARBA:ARBA00006708}.
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DR EMBL; KN121896; KFO34889.1; -; Genomic_DNA.
DR RefSeq; XP_010618333.1; XM_010620031.2.
DR RefSeq; XP_010618334.1; XM_010620032.2.
DR RefSeq; XP_010618335.1; XM_010620033.1.
DR RefSeq; XP_010618336.1; XM_010620034.2.
DR RefSeq; XP_010618337.1; XM_010620035.1.
DR AlphaFoldDB; A0A091DRW7; -.
DR STRING; 885580.ENSFDAP00000008989; -.
DR Ensembl; ENSFDAT00000022012; ENSFDAP00000008989; ENSFDAG00000017111.
DR GeneID; 104859438; -.
DR CTD; 2886; -.
DR eggNOG; KOG3751; Eukaryota.
DR OMA; RCFCFLR; -.
DR OrthoDB; 3144731at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16140; RA_GRB7; 1.
DR CDD; cd10413; SH2_Grb7; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR015042; BPS-dom.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR046986; GRB7_RA.
DR InterPro; IPR035032; Grb7_SH2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF25; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7; 1.
DR Pfam; PF08947; BPS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000313|EMBL:KFO34889.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 104..190
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 233..342
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 435..531
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..42
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 536 AA; 59552 MW; 97F38648C04CCDD2 CRC64;
MEPDLSPPCS GSPPEDLCPT PGTPPGTPPP GTPPPPEAPV PGEVVQSQPL PIPASRKLPE
EKRQATSLPS IPNPFPELCS PPSHSPILGG PSSARGLLPR DTSRPHVVKV YSEDGACRSV
EVAAGATARH VCEMLVQRTQ ALSDESWGLV ECHPHLALER GLEDHESVVD VQAVWPVGGD
SRFVFRKNFA KYELFKSSPH SLFPEKMVSS CLDAHTGVSH EDLIQDFLNA DSFPEIQGFL
QLRGSGRKLW KRCFCFLRRS GLYFSTKGTS KDPRHLQYVA DVNESNVYVV TQGRKLYGLP
TDFGFCVKPN KLRNGHKGLR VFCSEDEQSR TCWLAAFRLF KYGVQLYKNY QQAQSRHPRP
SSLGSQPLRS VSDNTLVAMD FSGHAGRVIE NPREALSAAL EEAQAWRRKT NHRLSLPTPS
SGTSLSTAIH RTQPWFHGRI SREESQRLIG QQGLVDGLFL VRESQRNPHG FVLSLCHLQK
VKHYLILPSE AEGGLYFSMD DGQTRFTDLL QLVEFHQLNR GLLPCLLRHC CTRVAL
//
