ID A0A091DTD9_FUKDA Unreviewed; 369 AA.
AC A0A091DTD9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Betaine--homocysteine S-methyltransferase 2 {ECO:0000313|EMBL:KFO35419.1};
GN ORFNames=H920_03152 {ECO:0000313|EMBL:KFO35419.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO35419.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO35419.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO35419.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the regulation of homocysteine metabolism.
CC {ECO:0000256|PIRNR:PIRNR037505}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRNR:PIRNR037505,
CC ECO:0000256|PIRSR:PIRSR037505-2};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRNR:PIRNR037505,
CC ECO:0000256|PIRSR:PIRSR037505-2};
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005137, ECO:0000256|PIRNR:PIRNR037505}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|PIRNR:PIRNR037505}.
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DR EMBL; KN121800; KFO35419.1; -; Genomic_DNA.
DR RefSeq; XP_010617390.1; XM_010619088.2.
DR AlphaFoldDB; A0A091DTD9; -.
DR STRING; 885580.ENSFDAP00000019782; -.
DR Ensembl; ENSFDAT00000012466; ENSFDAP00000019782; ENSFDAG00000008910.
DR GeneID; 104858761; -.
DR CTD; 23743; -.
DR eggNOG; KOG1579; Eukaryota.
DR OMA; ENMESKW; -.
DR OrthoDB; 66796at2759; -.
DR UniPathway; UPA00051; UER00083.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0008172; F:S-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.330; Homocysteine-binding-like domain; 1.
DR InterPro; IPR017226; Betaine-hCys_S-MeTrfase_BHMT.
DR InterPro; IPR003726; HCY_dom.
DR InterPro; IPR036589; HCY_dom_sf.
DR PANTHER; PTHR46120; BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1; 1.
DR PANTHER; PTHR46120:SF3; S-METHYLMETHIONINE--HOMOCYSTEINE S-METHYLTRANSFERASE BHMT2; 1.
DR Pfam; PF02574; S-methyl_trans; 1.
DR PIRSF; PIRSF037505; Betaine_HMT; 1.
DR SUPFAM; SSF82282; Homocysteine S-methyltransferase; 1.
DR PROSITE; PS50970; HCY; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PIRNR:PIRNR037505,
KW ECO:0000256|PIRSR:PIRSR037505-2};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR037505};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037505};
KW Zinc {ECO:0000256|PIRNR:PIRNR037505, ECO:0000256|PIRSR:PIRSR037505-2}.
FT DOMAIN 17..311
FT /note="Hcy-binding"
FT /evidence="ECO:0000259|PROSITE:PS50970"
FT BINDING 214
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037505-2,
FT ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 296
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037505-2,
FT ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 297
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR037505-2,
FT ECO:0000256|PROSITE-ProRule:PRU00333"
SQ SEQUENCE 369 AA; 40606 MW; F508E4D7384BAC72 CRC64;
MPAEPEMAPT GGPRPKRGIL ERLDQGEVVI GDGSFLITLE KRGYVKAGLW TPEAVVEHPD
AVRQLHMEFL RAGSNVMQTF TFSASEDSMD SKWEEVNSAA CDLAKEVAGK GDALVAGGIC
QSSMYKYHKD EARIKKLFRL QLEVFARKNV DFLIAEYFEH VEEAVWAVEV LKELGKPVAV
TMCIGPEGDM HGVTPGGCAV QLAKAGADII GVNCRFGPRT SLQTLCFMKQ GLGAVGLSPH
LMVQPLGFHT PDCGKGGFVD LPEYPFGLEP RVATRWDIQK YAREAYNLGV RYIGGCCGFE
PYHIRAIAEE LAPERGFLPP ASEKHGSWGS ALNMHTKPWI RARARREYWE NLLPASGRPF
CPSLSKPDV
//
