ID A0A091DTH5_FUKDA Unreviewed; 1850 AA.
AC A0A091DTH5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Myosin-Vb {ECO:0000313|EMBL:KFO34392.1};
GN ORFNames=H920_04214 {ECO:0000313|EMBL:KFO34392.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO34392.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO34392.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO34392.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KN121968; KFO34392.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000022452; -.
DR eggNOG; KOG0160; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd15477; Myo5b_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 3.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR037990; Myo5b_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF356; UNCONVENTIONAL MYOSIN-VB; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 5.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 6.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 5.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 15..67
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 76..776
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1528..1805
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 655..677
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1088..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1169..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1204..1266
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1335..1442
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1100..1127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 177..184
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1850 AA; 214040 MW; 4A20B6139E68AF13 CRC64;
MEGEGIQGTI CTLALTYTRV WIPDPDEVWR SAELTQDYRE GEKSLQLKLE DETIREYPID
VQSNQLPFLR NPDILVGEND LTALSYLHEP AVLHNLKVRF LESNHIYTYC GYPADIPGIV
LVAINPYEQL PIYGQDVIYA YSGQNMGDMD PHIFAVAEEA YKQMARDEKN QSIIVSGESG
AGKTVSAKYA MRYFATVGGS ASETNIEEKV LASSPIMEAI GNAKTTRNDN SSRFGKYIQI
GFDKRYHIIG ANMRTYLLEK SRVVFQADGE RNYHIFYQLC AAASLPEFKE LALTCAEDFF
YTSQGGDTSI EGISDAEDFE KTRQAFTLLG VRESHQITIF KIIASILHLG SVEIQAERDG
DSCSISPQDQ HLSNFCCLLG VEHSQMEHWL CHRKLVTTSE TYVKTMSLQQ VVNARNALAK
HIYAQLFSWI VDHINKALHT SLKQHSFIGV LDIYGFETFE INSFEQFCIN FANEKLQQQF
NSHVFKLEQE EYMKEQIPWT LIDFYDNQPC IDLIEAKLGI LDLLDEECKV PKGTDQNWVQ
KLYDRHSSSQ HFQKPRMSSM SFIVIHFADK VEYLSDGFLE KNRDTVYEEQ INILKASKFP
LVSDLFHDDK DATPATTPAG KGSSSKINVR SAKPLLKASN KEHKKTVGLQ FRNSLNRLME
TLNATTPHYV RCIKPNDDKL PFHFDPKRAV QQLRACGVLE TIRISAAGYP SRWTYHDFFN
RYRVLVKKRD LSNTDKKAIC KSVLESLIKD PDKFQFGRTK IFFRAGQVAY LEKLRADKFR
AATIMIQKTV RGWLQKVKYQ RLKKATMTLQ RYCRGYLARR LAEHLRRTRA AVVFQKQYRM
LRAQRAYQRV HRAAVIIQAF ARAMFVRRIY RQVLMEHKAT IIQKHARGWM ARRCFWRLRD
AAIVIQCAFR RLKAKQELKA LKIEARSAEH LKRLNVGMEN KVVQLQRKID DQNKEHKTLL
EQLSAVTITH ATEMEKLERE LAHYQQLQKE VQSLHTELQR AHSEREVLED AHSKEKDELR
KRVTDLEQEN ALLKDEKEQL NNQILCQLKD EFAQNSMKEN LLMKKELEEE RSRYQNLVKE
YSRLEQRYDN LRDEQTPGHR RNPSNQSSLE SDSNYPSIST SEVGDTEDTL QQVEEIGVDK
AAMDMTVFLK LQKRVRELEQ ERKKLQVQLE KREQQESKKG QMEQPRNDIE LDQDSDLAYN
SLKRQELESE NKKLKNDLNE LRKAVADQAT QNNSPHSSPD SYSLLLNQLK LANEELEVRK
EEVLILRTQI MNADQRRLAG KSTEPNINAR TSWPNSEKHV DQEDAIEAYH GVCQTNSQTE
DWGYLNEDGE LGLAYQGLKQ VARLLEAQLQ AQSLEHEEEV ESLKAQVEAL KEELDKQQQT
FCQTLLLSPE AQVEFGVQQE ISWLTNENLD LKELVEKLEK NERKLKKQLK IYMKKVQDLE
AAQALAQSDT RRHELTRQVT VQRKEKDFQG MLEYHKEDEA LLIRNLVKDL KPQMLSGTVP
CLPAYILYMC IRHADYTNDD LKVHSLLTST ISGIKKVLKK HNDDFEMTTF WLSNTCRLLH
CLKQYSGDEG FMTQNTAKQN EHCLKNFDLT EYRQVLSDLS IQIYQQLIKI AEGLLQPMIV
SAMLENESIQ GLSGVKPMGY RKRSSSMVDG DNSYCLEAII HQMNSFHMVM CEQGLDPEII
LQVFKQLFYM INAVTLNNLL LRKDICSWST GMQLRYNISQ LEEWLRGRNL HQSGAVQTME
PLIQAAQLLQ LKKKTHEDAE AICSLCTSLS TQQIVKILTL YTPLNEFEER VTVSFIRTIQ
AQLQERNDPQ QLLLDFKHMF PVLFPFNPSS LTMDSIHIPS CLKLEFLNEV
//
