ID A0A091E4P3_FUKDA Unreviewed; 1779 AA.
AC A0A091E4P3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN ORFNames=H920_00269 {ECO:0000313|EMBL:KFO38317.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO38317.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO38317.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO38317.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; KN120547; KFO38317.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000013031; -.
DR Ensembl; ENSFDAT00000030552; ENSFDAP00000013031; ENSFDAG00000020361.
DR eggNOG; KOG2301; Eukaryota.
DR OMA; VEIDMFP; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 5.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF210; SODIUM CHANNEL PROTEIN TYPE 11 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:KFO38317.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 263..282
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 455..477
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 631..651
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 705..730
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 795..822
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1065..1083
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1129..1149
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1175..1206
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1284..1307
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1357..1380
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1400..1418
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1430..1449
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1496..1518
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1530..1552
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1572..1598
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 185..420
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 597..832
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 837..1059
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1063..1316
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1364..1608
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 83..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1779 AA; 202455 MW; 0E8E0FE1C5F98FF6 CRC64;
MGGTAAARAD VPHLDANPGT GLLIGWREGD RQVLSACQYL EEATRRLKMA DRCYPVIFPD
ERNFRPFTSD SLAAIEKRIA IQKEKKKSKD KTASEPPPRP QLDLKVSRKL PKLYGNIPRD
LVAKPLEDLD PFYRNHKTFM VLNKKRTIYR FSAKRALFIF GPFNPIRSLA IRILVHSYPS
VNMFIICTVI VNCLFMTMAG VKESKRTGPD VAEIADLNPS SPIKLLSLRT FRVIRALKAI
SVVSGLKVIV GALLRSVKKL VDVMVLTLFC LCIFALVGQQ LFQGILSQKC VKIGCDTTGE
TNGKIFRVSV DSCFAKEINS TEPIMCGNWS AGRCPPDSRC KTTGINPDYN YTNFDNFGWS
LLAMFRLMTQ DSWEKLYRQT LHTAGPYSVF FFVVVIFLGS FYLINLTLAV VTMAYEEQSR
NVAAETEAKE KMFQEAQKLI KEEKETLHTA GPYSVFFFVV VIFLGSFYLI NLTLAVVTMA
YEEQSRNVAA ETEAKEKMFQ EAQKLIKEEK EPPLLEQTKQ LSQNLPVDVS DEHGDPLQRQ
RALSAVSIIT ITMKEQEKLQ QPCLPCGEKL ISKYLVWNCS PKWLYIKKAL RVVMTDPFTE
LAITICIIIN TIFLAMEHHG MDMNFKIMLQ TGNWVFTIIF MAEMCLKIIA LDPYHYFRHS
WNIFDSIVVV VSLAEIIAGD YVSLRSFRVL RVFKLAKSWP TLNTLIKIIS HSFGALGNLT
MVLVIVLFIF SAVGMQLFGN KFCSTRNSTS CSSVTNSCQR RWHMGDFYHS FLVVFRILCG
EWIENMWECM REVNIPLCVI VFVLIMVIGK LVVLNLFIAL LLNSFNNEER NENQGEAKKT
KVQLALDRIS WAFSFVIRTL QHFCHKWFRR QKLPKQEETT EGSATDSKGI PQVSEMKGGS
ETQEEFDGPA SARRTLGVGC DHIWLAPLAQ EEDDPGYIDR EEELPITPPD AARQDCGHQE
TKKPTSPGVQ SVEIDVFSED FSLTTQNPQK KSDAISVLSE CSTIDLQDPV GNLYKMVHPS
KQPERCLPKG LSSFLPCCKM DKRKSLWVIW WNLRKTCYQI VKHSWFESFI IFVILLSSGA
LVFEDIHLSN YRHIQNLLNC TDNIFTSIFV LEMALKWVAF GFSKYFTNAW CWLDFIIVVV
SLVVSFVDLQ QWKAFRTLRA LRPLRALSRF EGMKVVVNAL IGAIPAIVNV LFVCLIFWLI
FCILGVNLFS GKFGNVANYT ILPDGKCTQN YTWNPPNVNF DHVGMAYLAL LQVATYKGWM
EIMYAAVDST KDGPPQFEAH VVMYVYFIAF IIFGSFFTLN LFIGVIIDNF NQQQKKISGQ
DIFMTEEQKK YYNAMKKLGT KKPLKPIPRP LNKCQGLVFD VVTHQVFDVF IMSLIVLNMV
CMMVETRDQS SYTDSVLEHL NTIFVIIFTA ECLIKVFALR QYYFINGWNL FDCVVVVLSI
ISTMVTLVGK NNTIPFPPTL FRIVRLARIG RILRLVRAAR GIRTLLFALM MSLPSLFNIG
LLLFLVMFIY AIFGMNYFCK MERKGGIDDI FNFDTFAGSM LCLFQITTSA GWDALLNPML
GPSPPGKPYP YGIAIAYFVS YIIISFLIVV NMYIAVILEN FNVATEESEE PLGEDDFEMF
YEVWEKFDPE ATQFIKYSAL SDFADALPEP LRVAKPNKFQ FLMMDLPMVS GDRLHCMDIL
FAFTTKVLGE SSGLDTMKTM MEEKFMEANP FKKLYEPIVT TTKRKAEEEG AAVIQKAFRK
YMVNVTRCAV EDRPPSPLQA LSNGDLSGSE VAKRKVHYD
//
