ID A0A091E8F1_FUKDA Unreviewed; 498 AA.
AC A0A091E8F1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Keratin, type II cuticular Hb6 {ECO:0000313|EMBL:KFO31441.1};
GN ORFNames=H920_07182 {ECO:0000313|EMBL:KFO31441.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO31441.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO31441.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO31441.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; KN122282; KFO31441.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091E8F1; -.
DR STRING; 885580.ENSFDAP00000023066; -.
DR eggNOG; ENOG502RTZU; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF52; KERATIN, TYPE II CUTICULAR HB6; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 107..430
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 235..262
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 328..408
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 498 AA; 54604 MW; CC3AC6963F6D7201 CRC64;
MTCGSYCGGR AFSCASASCG PRPGRCCITA APYRGISCYR GLTGGFGSRS VCGAFRSGSC
GRSFGYRSGG ICGPSPPCIT SVSVNESLLT PLNLDIDPNA QCVKHEEKEQ IKCLNSKFAA
FIDKVRFLEQ QNKLLETKLQ FYQNRECCQS NLEPLFEGYI QTLRREAECV EADSGRLAAE
LNHAQEVLEG FKKKYEEEVS LRATAENEFV ALKKASSMGM GSRDTRDVDY AYLRRSDLEA
NAEALTQEID FLRRLYEEEI RVLQSHISDT SVIVKMDNSR ELNMDCVVAE IKAQYDDIAT
RSRAEAESWY RTRCEEIKAT VIRHGETLRR TREEINELNR IIQRLTAEIE NAKCQNTKLE
TAVTQSEQQG EAALNDARCK LAGLEEALQK AKQDMACLLK EYQEVMNSKL GLDIEIATYR
RLLEGEEQRL CEGVGSVSVC VSSSRGGIAC GDLCASSTSP AVNTRVCSAP SGNVVVGAPN
ACAPCAGVSA CSSGCKKC
//
