ID A0A091EBY3_FUKDA Unreviewed; 399 AA.
AC A0A091EBY3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Arylacetamide deacetylase {ECO:0000313|EMBL:KFO32806.1};
GN ORFNames=H920_05828 {ECO:0000313|EMBL:KFO32806.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO32806.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO32806.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO32806.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family.
CC {ECO:0000256|ARBA:ARBA00010515}.
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DR EMBL; KN122131; KFO32806.1; -; Genomic_DNA.
DR RefSeq; XP_010623624.1; XM_010625322.2.
DR AlphaFoldDB; A0A091EBY3; -.
DR STRING; 885580.ENSFDAP00000016656; -.
DR ESTHER; fukda-a0a091eby3; Arylacetamide_deacetylase.
DR Ensembl; ENSFDAT00000008073; ENSFDAP00000016656; ENSFDAG00000005263.
DR GeneID; 104863060; -.
DR eggNOG; KOG1515; Eukaryota.
DR OMA; QNQYMPI; -.
DR OrthoDB; 1144477at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR InterPro; IPR017157; Arylacetamide_deacetylase.
DR InterPro; IPR033140; Lipase_GDXG_put_SER_AS.
DR PANTHER; PTHR23025:SF3; HORMONE-SENSITIVE LIPASE; 1.
DR PANTHER; PTHR23025; TRIACYLGLYCEROL LIPASE; 1.
DR Pfam; PF07859; Abhydrolase_3; 2.
DR PIRSF; PIRSF037251; Arylacetamide_deacetylase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS01174; LIPASE_GDXG_SER; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 107..266
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
FT DOMAIN 315..375
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
FT ACT_SITE 189
FT /evidence="ECO:0000256|PIRSR:PIRSR037251-1,
FT ECO:0000256|PROSITE-ProRule:PRU10038"
FT ACT_SITE 343
FT /evidence="ECO:0000256|PIRSR:PIRSR037251-1"
FT ACT_SITE 373
FT /evidence="ECO:0000256|PIRSR:PIRSR037251-1"
SQ SEQUENCE 399 AA; 45784 MW; 496C31FABE1029B2 CRC64;
MGRKSLYFLV LGVLVACYIY TSPPDIFEEP WKLMLINVQL KTFVHLTTFI EFLGLYHFAD
LLVLTATFEE VPPNSDENVT VTETKFDNVP VRVYVPKRKL DAHRRAVFFV HGGGWCSGSP
ALRNYDLLSR WTAERLNAVV ISIDYRLAPK YHFPIQFEDV YNALRWFLRR NILENYGINP
ERICVSGDSA GGNLAAAVTQ KLFSDSDANI KPKIQALIYP ALQPLDLDSP SYQENSDMPI
LPKSLMVRFW SEYFTRDRSL EKAMLSNEHV SAESSHLFQF VNWSSFLPER FRKGHVYNNP
TYGSSELTQK YPGILDVRAA PLLADDSKLR GLPQTFVLTC QYDVLRDDGL MYVTRLRNAG
VQVAHYHVED GFHGAISFPQ LKISHRVINQ YISWLKENL
//
