ID A0A091EI09_CORBR Unreviewed; 675 AA.
AC A0A091EI09;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 36.
DE SubName: Full=Calpain-8 {ECO:0000313|EMBL:KFO56726.1};
DE Flags: Fragment;
GN ORFNames=N302_00824 {ECO:0000313|EMBL:KFO56726.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO56726.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO56726.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO56726.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; KK718445; KFO56726.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091EI09; -.
DR STRING; 85066.A0A091EI09; -.
DR MEROPS; C02.007; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR CDD; cd16191; EFh_PEF_CAPN8; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF374; CALPAIN-8; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000052976};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 13..312
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 576..611
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT ACT_SITE 73
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 230
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 254
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO56726.1"
FT NON_TER 675
FT /evidence="ECO:0000313|EMBL:KFO56726.1"
SQ SEQUENCE 675 AA; 76845 MW; 6C25C321B2A710E7 CRC64;
EALKQQCLQT GTLFKDEEFP ACPSALGYRD LGPYSFKTQG IVWKRPTELC ANPQFIVGGA
TRTDVCQGEL GDCWLLAAIA SLTLNPDILF RVVPKAQSFQ KDYAGIFHFQ FWQYGEWVDV
VVDDRLPTKN GKLLFVHSEE GNEFWSALLE KAYAKLNGSY EALAGGSTVE GFEDFTGGIS
ESYELQRAPS NLYQIIQKAL RAGSLLGCSI DITATAEIEA VTSLKLVKGH AYSITGAEEV
YYRGRPEKLV RLRNPWGEVE WTGSWSDNAP EWNYVDPKQK QALDKQVDDG EFWMAFSDFQ
RQFSRLEICN LTPDTLSSNE VNKWDLTLFN GQWRRGSTAG GCQNYQATYW TNPQFKIRLE
EPDDDHEGSL NEPCCTVLVG LMQKNRRRQK RMGEDLLSIG YSLYQVKRTH SPQLEDSTDV
HAGRAFFARH QPAARTDPYM NLREVSRRMT LPRGQYLIVP STFEPYKNGE FCLRVFAEKQ
AKSQMMSDEV SARPYEPHVD NKDVDDEFKT LFQKLSGEDC EVTATELQRI LNQVLAKRKD
VKSDGFNINT CREMISLLDT DGTGTLGLIE FKTLWMKIQN YLAIYKKVDS DYSGTIDSHE
MRNALREAGF RLNDEVQHSI VTRYACSTKL TIDFDGFVAC MIRLETLFKV FHLLDKDKNG
VIQISLPEWL CCTLV
//
