ID A0A091ERN5_CORBR Unreviewed; 1391 AA.
AC A0A091ERN5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
DE Flags: Fragment;
GN ORFNames=N302_02245 {ECO:0000313|EMBL:KFO59651.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO59651.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO59651.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO59651.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR EMBL; KK718902; KFO59651.1; -; Genomic_DNA.
DR STRING; 85066.A0A091ERN5; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14630; R-PTPc-T-1; 1.
DR CDD; cd14634; R-PTPc-T-2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF8; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:KFO59651.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000052976};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..121
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 123..214
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 221..314
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 319..413
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 414..520
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 834..1094
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1014..1085
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1126..1388
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1302..1379
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 706..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO59651.1"
FT NON_TER 1391
FT /evidence="ECO:0000313|EMBL:KFO59651.1"
SQ SEQUENCE 1391 AA; 156708 MW; C35985A1B3F09CCF CRC64;
AGSFMMVNSS GRASGQKAHL LLPTLKENDT HCIDFHYYLS SRDRSSPGSL NVYVKVNGGP
QGNPIWNVSG VVTEGWVKAE LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR
KAPHFLRLQN VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA
TVSVADTSQR SISKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV GATYLWIKPN
ANSIIGDGPI ILKEVEYRTT TGNWAETHIV DSPNYKLWHL DPDVEYEIRV LLTRPGEGGT
GPPGPPLTTR TKCADPVHGP QNVEVVDIRS RQLTLQWEPF GYAVTRCHSY NLTVHYQYVF
NQQKFEAEEL IQTSSHYTLR GLRPFMTIRL RLALSNPEGK MESEELVVQT EEDVPGPVPL
ESIQGGPFEE KIYVQWKPPN ETNGIITLYE ITYKAVGSLD PSADLSSQRG KVFKLRNETH
HLFVGLYPGT TYSFTIKAST VKGFGPPITT RIATKISAPS MPEYDTDSPL NETDTTITVM
LKPAQSRGAP VSVYQLVVKE EKLQKARRAA DIIECFSVPV SYKNASSLDS PHYFAAELKP
INLPVTQPFT VGDNKTYNGY WNAPLSPLKS YSIYFQALSK ANGETKINCV RLATKGASTQ
NSNAVEPEKQ VDSTVKMAGV IAGLLMFVII LLGAMLTIKR RKLAKKQKET QTSTQREMGP
VATSDKTSTK LSAVHNEEAF SSSCQDVNGF TSPSPCSFSV QSKTLQSKSM LNSYYSDSSH
GEMAQPTLTI QTHPYRSCEP VEMSYPQGQF QPAIRVADLL QHITQMKRGQ GYGFKEEYEA
LPEGQTASWD TAKEDENRNK NRYGNIISYD HSRVRLQLLD GDPHSDYINA NYIDGYHRPR
HYIATQGKFI LVWPMQETVK DFWRMIWQEN SASVVMVTNL VEVGRVKCVR YWPDDTEVYG
DIKVTLIETE PLAEYVIRTF TVQKKGYHEI REIRQFHFTS WPDHGVPCYA TGLLGFVRQV
KFLNPPEAGP IVVHCSAGAG RTGCFIAIDI MLDMAENEGV VDIFNCVREL RSQRVNLVQT
EEQYVFVHDA ILEACLCGNT AIPVCEFRSI YYNISRLDPQ TNSSQIKDEF QTLNIVTPRV
RPEDCSIGLL PRNHDKNRCM DVLPLDRCLP FLISVDGESS NYINAALMDS HKQPAAFIVT
QHPLPNTIAD FWRLVFDYNC SSVVMLNEMD AAQLCMQYWP EKTSCCYGPI QVEFVSADID
EDIINRIFRI CNMARPQDGY RIVQHLQYIG WPAYRDTPPS KRSLLKVVRR LEKWQEQYDG
RDGRTVVHCL NGGGRSGTFC AICSVCEMIQ QQNIIDVFHI VKTLRNNKSN MVESLEQYKF
VYEVALEYLS S
//
