ID A0A091F9E3_CORBR Unreviewed; 499 AA.
AC A0A091F9E3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Frizzled-2 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=N302_11378 {ECO:0000313|EMBL:KFO65154.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO65154.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO65154.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO65154.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; KK719701; KFO65154.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091F9E3; -.
DR STRING; 85066.A0A091F9E3; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15245; 7tmF_FZD2; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF34; FRIZZLED-2; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000052976};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 180..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..92
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 178..481
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DISULFID 12..73
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 20..66
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO65154.1"
FT NON_TER 499
FT /evidence="ECO:0000313|EMBL:KFO65154.1"
SQ SEQUENCE 499 AA; 56440 MW; E542B17851D4E132 CRC64;
EKGISIPDHG FCQPISIPLC TDIAYNQTIM PNLLGHTNQE DAGLEVHQFY PLVKVQCSLE
LKFFLCSMYA PVCTVLEQAI PPCRSICERA RQGGQGWHSG EDGGSPALLT SATPLAGQGT
PGAPRYATLD PPFHCPRALK VPSYLNYKFL GEKDCAAPCE PTRPDGHMFF NEDEIRFARI
WILIWSVLCC ASTFFTVTTY LVDMQRFRYP ERPIIFLSGC YTMVSVAYIA GFVLEERVVC
NERFQEDGYR TVVQGTKKEG CTILFMMLYF FSMASSIWWV ILSLTWFLAA GMKWGHEAIE
ANSQYFHLAA WAVPAVKTIT ILAMGQIDGD LLSGVCFVGL NNIDPLRGFV LAPLFVYLFI
GTSFLLAGFV SLFRIRTIMK HGGTKTEKLE RLMVRIGVFS VLYTVPATIV IACYFYEQAF
REHWERSWIS QNCKSLAIPC PLHFTPRMTP DFTVYMIKYL MTLIVGITSG FWIWSGKTLH
SWRKFYTRLT NSKQGETTV
//
