ID A0A091FYY7_9AVES Unreviewed; 339 AA.
AC A0A091FYY7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Adenosine receptor A2 {ECO:0000256|RuleBase:RU201114};
GN ORFNames=N303_12425 {ECO:0000313|EMBL:KFO74366.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO74366.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO74366.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO74366.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for adenosine. The activity of this receptor is
CC mediated by G proteins which activate adenylyl cyclase.
CC {ECO:0000256|ARBA:ARBA00024642, ECO:0000256|RuleBase:RU201114}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU201114}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU201114}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU201114}.
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DR EMBL; KL447514; KFO74366.1; -; Genomic_DNA.
DR RefSeq; XP_009556770.1; XM_009558475.1.
DR AlphaFoldDB; A0A091FYY7; -.
DR STRING; 55661.A0A091FYY7; -.
DR GeneID; 104057145; -.
DR KEGG; cuca:104057145; -.
DR CTD; 136; -.
DR OrthoDB; 2909020at2759; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001609; F:G protein-coupled adenosine receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001435; Adeno_A2B_rcpt.
DR InterPro; IPR001634; Adenosn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24246:SF18; ADENOSINE RECEPTOR A2B; 1.
DR PANTHER; PTHR24246; OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00554; ADENOSINA2BR.
DR PRINTS; PR00424; ADENOSINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU201114};
KW Disulfide bond {ECO:0000256|RuleBase:RU201114};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU201114};
KW Glycoprotein {ECO:0000256|RuleBase:RU201114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU201114};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU201114};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU201114};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU201114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU201114}.
FT TRANSMEM 6..31
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 43..71
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 77..99
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 183..210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 231..250
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 270..292
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT DOMAIN 22..290
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 339 AA; 37710 MW; 613974608903BE18 CRC64;
MDTLKTTYIA VELVIAVLSI AGNVLVCWAV AINSTLKNAT NYFLVSLAVA DIAVGLLAIP
FAITISIGFQ VDFHSCLFFA CFVLVLTQSS IFSLLAVAID RYLAIKIPLR YNSLVTGKRA
RGLIAVLWVL SFAIGLTPLM GWNKAMSGCP NATNETGTDT GTENHGCFIS CLFENVVTMS
YMVYFNFFGC VLLPLVIMLG IYIKIFMVAC KQLHQIELMG NSRTTLQKEV HAAKSLAIIV
GLFAFCWLPL HILNCITHFH EEFSKSKPEW VMYMAIILSH ANSVINPIIY AYRIRDFRYT
FRKIISKILC KADDFPKCTD NNQHLTVTNM NSPIASVTI
//
