ID A0A091G1A7_9AVES Unreviewed; 673 AA.
AC A0A091G1A7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 26.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
DE Flags: Fragment;
GN ORFNames=N303_04533 {ECO:0000313|EMBL:KFO75778.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO75778.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO75778.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO75778.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; KL447647; KFO75778.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091G1A7; -.
DR STRING; 55661.A0A091G1A7; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655:SF15; GUANYLATE CYCLASE; 1.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760}.
FT DOMAIN 486..614
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 420..458
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO75778.1"
FT NON_TER 673
FT /evidence="ECO:0000313|EMBL:KFO75778.1"
SQ SEQUENCE 673 AA; 77235 MW; B741234C207C3F43 CRC64;
YGFINTCLKS LVVEKYGEET WENLRRQAGV QDSFLTFEVY KDEITMQLVD KACKILGVPA
DMVLREFGEY FFEFCKRSGY DHMLRTLGGN LYEFIENLDA LHSYLSLSYQ ASIEVLVWFV
FPQEMNAPSF RVEKNEDGSM HLHYYSDRRG LCHIVPGIIG AAALDFFNIE ISMEIVNQTE
EEERTGKKEH IVFLVTQNPV FSYKERSKFS SLPQYLADSE KKIDSQLKKE DVEKAKNAIR
ERGSTVCPVR KSHWKTIRGI IALGKGKLLR GFDPVYPKSL WIDTKTFCNG LPFHMVFDKE
LRVKQAGVSI QKIVPGLQTM DISLDQYFSI VHPEVPFTIS SIQKFINSQF VFQTRREMMP
ESWKQRPMLE LRGQMIWMES LQCMLYLCSP LLRTLHELEE RQMHIADIAP HDVTRDLILL
NQQRLAEMEL SNQLERKKEE LRILSKHLEE EKKKTEALLY AMLPQHVANQ LKEGKQVEAG
EFKECTILFS DVVTFTNICA QCEPIQIVLM LNSMYLRFDR LTTVHDVYKV ETIGDAYMVV
GGVPVPVPTH AERVANFALG MIIAAKGVQN PVSGNPIQIR VGIHTGPVLA GVVGEKMPRY
CLFGDTVNIA SRMESHGVPS KIHLSSSAYQ CLKYKNFEMT ERGEIEVKGK GKMHTYFLIR
NKTATENEIM GRP
//
