ID A0A091GYJ1_BUCRH Unreviewed; 856 AA.
AC A0A091GYJ1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Leucine-rich repeat-containing protein 8D {ECO:0000313|EMBL:KFO88254.1};
GN ORFNames=N320_00473 {ECO:0000313|EMBL:KFO88254.1};
OS Buceros rhinoceros silvestris.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros.
OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO88254.1, ECO:0000313|Proteomes:UP000054064};
RN [1] {ECO:0000313|EMBL:KFO88254.1, ECO:0000313|Proteomes:UP000054064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO88254.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL516703; KFO88254.1; -; Genomic_DNA.
DR RefSeq; XP_010131998.1; XM_010133696.1.
DR AlphaFoldDB; A0A091GYJ1; -.
DR GeneID; 104491308; -.
DR KEGG; brhi:104491308; -.
DR CTD; 55144; -.
DR OrthoDB; 55205at2759; -.
DR Proteomes; UP000054064; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF3; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 4.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054064};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..382
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
FT REGION 64..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 97821 MW; 0CBBA085F5C6CC17 CRC64;
MFTLAEVASL NDIQPTYRIL KPWWDVFMDY LAVVMLMVAI FAGTMQLTKD QVVCLPVLQS
TVNSKAQPST SGKADFTTVE TTTGQGEDAS MRTVSFGRTP TVTPDVPLSR ATSPQYQPTE
SGQELKKEQK DSSGRKTNLD FQQYVFINQM CYHLALPWYS KYFPYLVLIH TIILIVSSNF
WFKYPKTCSK IEHFVSILGK CFESPWTTKA LSETACEDSE ENKQRLTGAQ SLPKYVSTSS
DEGSPSANTP MITKSGFKFS ADKPMIEVPS VTILDKKDGE QAKALFEKVR KFRAHVEDSD
LIYKLYVGQT VIKTVKFIFI LCYTANFVNT ISFEHICNPK VEHLIGYTQF ECTHNMAYML
KKLLISYISL ICVYGFICLY TLFWLFRIPL KEYSFEKVRE ESSFSDIPDV KNDFAFLLHM
VDQYDQLYSK RFGVFLSEVS ENKLREISLN HEWTFEKLRQ HVSRNAQDKQ ELHLFMLSGV
PDAVFDLTDL DVLKLELIPE AKIPAKISQM TNLQELHLCH CPAKVEQTAF SFLRDHLRCL
HVKFTDVAEI PAWVYLLKNL RELYLIGNLN SENNKMIGLE SLRELRHLKI LYVKSNLTKI
PPNITDVAPH LTKLVILNDG TKLVVLNSLK KMTNVAELEL QNCELERIPH AIFSLSNLQE
LDLKSNSIRT IEEIISFQHL KRLTCLKLWH NKIVNIPSSI THIKNLESLY LSNNKLESLP
AAVFSLQKLR CLDVSYNSIA LIPAEIGLLQ NLQHFHITGN KVDTLPKQLF KCVKLRTLSL
GQNYITSIPD KIGQLLQLTH LELKGNCLDH LPATLRQCQL LRKSGLVVED HLFDTLPLEV
KEVLNQDTSI PFANGI
//
